Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough
The association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
|
| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007119301777 |
| _version_ | 1818521382231736320 |
|---|---|
| author | Andrew R. Deitchman Or Kalchiem-Dekel Nevins Todd Robert M. Reed |
| author_facet | Andrew R. Deitchman Or Kalchiem-Dekel Nevins Todd Robert M. Reed |
| author_sort | Andrew R. Deitchman |
| collection | DOAJ |
| description | The association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral prodrome. He continued to decompensate despite high dose corticosteroids and mycophenolate mofetil, ultimately requiring extracorporeal membranous oxygenation as a bridge to bilateral lung transplantation. Clinically amyopathic dermatomyositis (CADM) was confirmed through serum positivity for anti-Melanoma Differentiation Associated Protein-5 (MDA-5) antibody. Interestingly, his post-operative course was complicated by a zoonotic infection with Bordetella bronchiseptica. This case highlights the importance of identifying rare autoimmune diseases, and the utility of transfer to a lung transplant center. |
| first_indexed | 2024-12-11T01:50:16Z |
| format | Article |
| id | doaj.art-1c9ca6bc01e74144b3566df7d881b86a |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-11T01:50:16Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-1c9ca6bc01e74144b3566df7d881b86a2022-12-22T01:24:46ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0128Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel coughAndrew R. Deitchman0Or Kalchiem-Dekel1Nevins Todd2Robert M. Reed3Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Corresponding author. 110 S. Paca St., 2nd floor, Baltimore, MD 21201, USADivision of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, USAThe association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral prodrome. He continued to decompensate despite high dose corticosteroids and mycophenolate mofetil, ultimately requiring extracorporeal membranous oxygenation as a bridge to bilateral lung transplantation. Clinically amyopathic dermatomyositis (CADM) was confirmed through serum positivity for anti-Melanoma Differentiation Associated Protein-5 (MDA-5) antibody. Interestingly, his post-operative course was complicated by a zoonotic infection with Bordetella bronchiseptica. This case highlights the importance of identifying rare autoimmune diseases, and the utility of transfer to a lung transplant center.http://www.sciencedirect.com/science/article/pii/S2213007119301777 |
| spellingShingle | Andrew R. Deitchman Or Kalchiem-Dekel Nevins Todd Robert M. Reed Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough Respiratory Medicine Case Reports |
| title | Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough |
| title_full | Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough |
| title_fullStr | Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough |
| title_full_unstemmed | Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough |
| title_short | Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough |
| title_sort | rapidly progressive interstitial lung disease due to anti melanoma differentiation associated protein 5 requiring a bilateral lung transplant and complicated by kennel cough |
| url | http://www.sciencedirect.com/science/article/pii/S2213007119301777 |
| work_keys_str_mv | AT andrewrdeitchman rapidlyprogressiveinterstitiallungdiseaseduetoantimelanomadifferentiationassociatedprotein5requiringabilaterallungtransplantandcomplicatedbykennelcough AT orkalchiemdekel rapidlyprogressiveinterstitiallungdiseaseduetoantimelanomadifferentiationassociatedprotein5requiringabilaterallungtransplantandcomplicatedbykennelcough AT nevinstodd rapidlyprogressiveinterstitiallungdiseaseduetoantimelanomadifferentiationassociatedprotein5requiringabilaterallungtransplantandcomplicatedbykennelcough AT robertmreed rapidlyprogressiveinterstitiallungdiseaseduetoantimelanomadifferentiationassociatedprotein5requiringabilaterallungtransplantandcomplicatedbykennelcough |