MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response.

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response.

Pathogen recognition and triggering of the inflammatory response following infection in mammals depend mainly on Toll-like and Nod-like receptors. Here, we evaluated the role of Nod1, Nod2 and MyD88-dependent signaling in the chemokine production and neutrophil recruitment to the infectious site dur...

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Main Authors: Fabiane Sônego, Fernanda V S Castanheira, Paula G Czaikoski, Alexandre Kanashiro, Fabricio O Souto, Rafael O França, Daniele C Nascimento, Andressa Freitas, Fernando Spiller, Larissa D Cunha, Dario S Zamboni, José C Alves-Filho, Fernando Q Cunha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4118952?pdf=render

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