Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review
IntroductionActive surveillance is considered a viable option for papillary thyroid microcarcinoma. Since the last decade of the 20th century, this method has spread from Japan to other countries, but has not yet been fully accepted and validated by the major Western Scientific Societies. In 2016, a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.859461/full |
| _version_ | 1819174541446873088 |
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| author | Giuseppina Orlando Gregorio Scerrino Alessandro Corigliano Irene Vitale Roberta Tutino Stefano Radellini Francesco Cupido Giuseppa Graceffa Gianfranco Cocorullo Giuseppe Salamone Giuseppina Melfa |
| author_facet | Giuseppina Orlando Gregorio Scerrino Alessandro Corigliano Irene Vitale Roberta Tutino Stefano Radellini Francesco Cupido Giuseppa Graceffa Gianfranco Cocorullo Giuseppe Salamone Giuseppina Melfa |
| author_sort | Giuseppina Orlando |
| collection | DOAJ |
| description | IntroductionActive surveillance is considered a viable option for papillary thyroid microcarcinoma. Since the last decade of the 20th century, this method has spread from Japan to other countries, but has not yet been fully accepted and validated by the major Western Scientific Societies. In 2016, a systematic review on the results of active surveillance was published, based on two articles that showed encouraging results. Other reviews published subsequently, were mainly based on articles from the Far East. The aim of this review is to assess the most recent results published from 2017 to 2020 on this subject.Materials and MethodsA systematic literature search was performed on MEDLINE via PUBMED, Web of Science, and Scopus according to PRISMA criteria. The MESH terms “papillary thyroid microcarcinoma” and “active surveillance” were adopted. Tumor progression, secondary localizations, and quality of life were the main benchmarks.ResultsNine studies met the inclusion criteria. The increase in volume ranged from 2.7% and 23.2%; the occurrence of lymph node metastases from 1.3% to 29%; QoL was improved in both articles that addressed this topic. The level of evidence is considered low due to the retrospective and uncontrolled nature of most of the studies included in the review.ConclusionThe evidence from the literature currently available on AS falls into two strands: a robust data set from the Japanese experience, and an initial experience from Western countries, whose data are still limited but which show a lack of substantial alerts against this practice. Further data is useful to validate the spread of Active Surveillance. |
| first_indexed | 2024-12-22T20:40:37Z |
| format | Article |
| id | doaj.art-1c9d8b70a1724decafc97ab8465c891b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T20:40:37Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1c9d8b70a1724decafc97ab8465c891b2022-12-21T18:13:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.859461859461Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic ReviewGiuseppina Orlando0Gregorio Scerrino1Alessandro Corigliano2Irene Vitale3Roberta Tutino4Stefano Radellini5Francesco Cupido6Giuseppa Graceffa7Gianfranco Cocorullo8Giuseppe Salamone9Giuseppina Melfa10Department of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalySection of Endocrinology - Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Oncology Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyDepartment of Surgical Oncology and Oral Sciences, Unit of General and Emergency Surgery, University of Palermo, Palermo, ItalyIntroductionActive surveillance is considered a viable option for papillary thyroid microcarcinoma. Since the last decade of the 20th century, this method has spread from Japan to other countries, but has not yet been fully accepted and validated by the major Western Scientific Societies. In 2016, a systematic review on the results of active surveillance was published, based on two articles that showed encouraging results. Other reviews published subsequently, were mainly based on articles from the Far East. The aim of this review is to assess the most recent results published from 2017 to 2020 on this subject.Materials and MethodsA systematic literature search was performed on MEDLINE via PUBMED, Web of Science, and Scopus according to PRISMA criteria. The MESH terms “papillary thyroid microcarcinoma” and “active surveillance” were adopted. Tumor progression, secondary localizations, and quality of life were the main benchmarks.ResultsNine studies met the inclusion criteria. The increase in volume ranged from 2.7% and 23.2%; the occurrence of lymph node metastases from 1.3% to 29%; QoL was improved in both articles that addressed this topic. The level of evidence is considered low due to the retrospective and uncontrolled nature of most of the studies included in the review.ConclusionThe evidence from the literature currently available on AS falls into two strands: a robust data set from the Japanese experience, and an initial experience from Western countries, whose data are still limited but which show a lack of substantial alerts against this practice. Further data is useful to validate the spread of Active Surveillance.https://www.frontiersin.org/articles/10.3389/fonc.2022.859461/fullpapillary thyroid microcarcinomaactive surveillancethyroidectomythyroid cancerquality of lifelymph node metastasis |
| spellingShingle | Giuseppina Orlando Gregorio Scerrino Alessandro Corigliano Irene Vitale Roberta Tutino Stefano Radellini Francesco Cupido Giuseppa Graceffa Gianfranco Cocorullo Giuseppe Salamone Giuseppina Melfa Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review Frontiers in Oncology papillary thyroid microcarcinoma active surveillance thyroidectomy thyroid cancer quality of life lymph node metastasis |
| title | Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review |
| title_full | Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review |
| title_fullStr | Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review |
| title_full_unstemmed | Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review |
| title_short | Papillary Thyroid Microcarcinoma: Active Surveillance Against Surgery. Considerations of an Italian Working Group From a Systematic Review |
| title_sort | papillary thyroid microcarcinoma active surveillance against surgery considerations of an italian working group from a systematic review |
| topic | papillary thyroid microcarcinoma active surveillance thyroidectomy thyroid cancer quality of life lymph node metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.859461/full |
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