Antinociceptive and anti-inflammatory activity of DW-1021, the ionic complex of pelubiprofen and tramadol, in rodents

Antinociceptive and anti-inflammatory activity of DW-1021, the ionic complex of pelubiprofen and tramadol, in rodents

Although drugs such as acetaminophen, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs), are commonly used for pain management, the side effects of these drugs such as hepatotoxicity, nephrotoxicity, nausea, and vomiting, can not be neglected. Therefore, combinations of analgesics with diff...

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Bibliographic Details
Main Authors: Young-Seo Yoon, Han-Jun Hwang, Jae-Min Kim, Kyung-Sook Chung, Seo-Yun Jang, So-Won Heo, Su-Yeon Lee, Soo-Yeon Kim, Hyeon-A. Song, Seung-Jae Hong, Hyo-Jin An, Sang-Wook Park, Jhong-Jae Im, Dong-Ho Oh, Ah-Ram Lee, Kyung-Tae Lee
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Drug combination
Tramadol
Pelubiprofen
Antinociception
Anti-inflammation
Synergic effect
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223004961

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