LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells

LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells

Abstract Background The aim of this study was to investigate how the signaling pathway downstream of mTOR/S6K1 contributes to the regulation of SREBP-1c expression during lipogenesis in HepG2 cells. Methods The model of steatosis was established using human hepatocytes HepG2 and inducting them with...

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Bibliographic Details
Main Authors: Youping Zhou, Shengjie Yu, Can Cai, Li Zhong, Huihong Yu, Wei Shen
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Nutrition & Metabolism
Subjects:
LXRα
mTOR
S6K1
NAFLD
HepG2 cells
Online Access:http://link.springer.com/article/10.1186/s12986-018-0268-9

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