Tumorous IRE1α facilitates CD8+T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma

Tumorous IRE1α facilitates CD8+T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma

Abstract Background Tumor cells frequently suffer from endoplasmic reticulum (ER) stress. Previous studies have extensively elucidated the role of tumorous unfolded protein response in melanoma cells, whereas the effect on tumor immunology and the underlying mechanism remain elusive. Methods Bioinfo...

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Main Authors: Yuqi Yang, Sijia Wang, Xiang-xu Wang, Sen Guo, Huina Wang, Qiong Shi, Yangzi Tian, Hao Wang, Tao Zhao, Hengxiang Zhang, Baolu Zhang, Tianwen Gao, Chunying Li, Xiuli Yi, Weinan Guo
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
ER stress
Melanoma
Immunosurveillance
Immunotherapy
Anti-PD-1 antibody
Online Access:https://doi.org/10.1186/s12964-024-01470-8

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