A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays
Erythrocyte enrichment is needed for blood disease diagnosis and research. DLD arrays with an I-shaped pillar (I-pillar) sort erythrocytes in a unique, accurate, and low-reagent method. However, the existing I-shaped pillar DLD arrays for erythrocyte sorting have the drawbacks of higher flow resista...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Fluids |
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| Online Access: | https://www.mdpi.com/2311-5521/8/5/161 |
| _version_ | 1797600141539016704 |
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| author | Jiangbo Wu Yao Lv Yongqing He Xiaoze Du Jie Liu Wenyu Zhang |
| author_facet | Jiangbo Wu Yao Lv Yongqing He Xiaoze Du Jie Liu Wenyu Zhang |
| author_sort | Jiangbo Wu |
| collection | DOAJ |
| description | Erythrocyte enrichment is needed for blood disease diagnosis and research. DLD arrays with an I-shaped pillar (I-pillar) sort erythrocytes in a unique, accurate, and low-reagent method. However, the existing I-shaped pillar DLD arrays for erythrocyte sorting have the drawbacks of higher flow resistance and more challenging fabrication. A two-dimensional erythrocyte simulation model and the arbitrary Lagrangian–Euler equations at the cell–fluid boundary were built based on the fluid–solid coupling method to investigate the influencing factors of the erythrocyte flow path in an I-pillar DLD array and find its optimization method. Three different sizes of I-pillars were built and multiple sets of corresponding arrays were constructed, followed by finite element simulations to separately investigate the effects of these arrays on the induction of erythrocyte motion paths. This work demonstrates the motion paths of erythrocyte models in a series of I-pillar arrays with different design parameters, aiming to summarize the variation modes of erythrocyte motion paths, which in turn provides some reference for designing and optimizing the pillar size and array arrangement methods for I-pillar array DLD chips. |
| first_indexed | 2024-03-11T03:44:23Z |
| format | Article |
| id | doaj.art-1ca4495e2a85490f80d95ec3413f2695 |
| institution | Directory Open Access Journal |
| issn | 2311-5521 |
| language | English |
| last_indexed | 2024-03-11T03:44:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj.art-1ca4495e2a85490f80d95ec3413f26952023-11-18T01:20:30ZengMDPI AGFluids2311-55212023-05-018516110.3390/fluids8050161A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD ArraysJiangbo Wu0Yao Lv1Yongqing He2Xiaoze Du3Jie Liu4Wenyu Zhang5School of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaChongqing Key Laboratory of Micro-Nano System and Intelligent Sensing, Chongqing Technology and Business University, Chongqing 400067, ChinaSchool of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaErythrocyte enrichment is needed for blood disease diagnosis and research. DLD arrays with an I-shaped pillar (I-pillar) sort erythrocytes in a unique, accurate, and low-reagent method. However, the existing I-shaped pillar DLD arrays for erythrocyte sorting have the drawbacks of higher flow resistance and more challenging fabrication. A two-dimensional erythrocyte simulation model and the arbitrary Lagrangian–Euler equations at the cell–fluid boundary were built based on the fluid–solid coupling method to investigate the influencing factors of the erythrocyte flow path in an I-pillar DLD array and find its optimization method. Three different sizes of I-pillars were built and multiple sets of corresponding arrays were constructed, followed by finite element simulations to separately investigate the effects of these arrays on the induction of erythrocyte motion paths. This work demonstrates the motion paths of erythrocyte models in a series of I-pillar arrays with different design parameters, aiming to summarize the variation modes of erythrocyte motion paths, which in turn provides some reference for designing and optimizing the pillar size and array arrangement methods for I-pillar array DLD chips.https://www.mdpi.com/2311-5521/8/5/161deterministic lateral displacementfinite element cell modelerythrocyte deformability |
| spellingShingle | Jiangbo Wu Yao Lv Yongqing He Xiaoze Du Jie Liu Wenyu Zhang A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays Fluids deterministic lateral displacement finite element cell model erythrocyte deformability |
| title | A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays |
| title_full | A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays |
| title_fullStr | A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays |
| title_full_unstemmed | A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays |
| title_short | A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays |
| title_sort | numerical study on the erythrocyte flow path in i shaped pillar dld arrays |
| topic | deterministic lateral displacement finite element cell model erythrocyte deformability |
| url | https://www.mdpi.com/2311-5521/8/5/161 |
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