Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells
Classical Hodgkin’s lymphoma (CHL) accounts for 10% of all lymphomas. Nodular sclerosis and mixed cellularity accounts for nearly 80% of all CHL cases. The number of mast cells in CHL correlates with poor prognosis, is significantly higher in nodular sclerosis than in other CHL subtypes, and an asso...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.964573/full |
| _version_ | 1828725230095302656 |
|---|---|
| author | Domenico Ribatti Roberto Tamma Tiziana Annese Tiziana Annese Giuseppe Ingravallo Giorgina Specchia |
| author_facet | Domenico Ribatti Roberto Tamma Tiziana Annese Tiziana Annese Giuseppe Ingravallo Giorgina Specchia |
| author_sort | Domenico Ribatti |
| collection | DOAJ |
| description | Classical Hodgkin’s lymphoma (CHL) accounts for 10% of all lymphomas. Nodular sclerosis and mixed cellularity accounts for nearly 80% of all CHL cases. The number of mast cells in CHL correlates with poor prognosis, is significantly higher in nodular sclerosis than in other CHL subtypes, and an association between the degree of angiogenesis and the number of intratumoral mast cells has been demonstrated in CHL. Even with the best available treatment, a significant percentage of CHL patients progress or relapse after first-line therapy. 50% of patients with disease relapse achieve subsequent long-term disease control with salvage therapies. In this context, new potential therapeutic opportunities are required, and mast cells may be regarded as a new target for adjuvant treatment of CHL through the inhibition of angiogenesis and tissue remodeling and allowing the secretion of cytotoxic cytokines. |
| first_indexed | 2024-04-12T13:23:38Z |
| format | Article |
| id | doaj.art-1ca548c187294d159b90645483d4757a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T13:23:38Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1ca548c187294d159b90645483d4757a2022-12-22T03:31:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.964573964573Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cellsDomenico Ribatti0Roberto Tamma1Tiziana Annese2Tiziana Annese3Giuseppe Ingravallo4Giorgina Specchia5Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, ItalyDepartment of Medicine and Surgery, Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Bari, ItalyDepartment of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, ItalyDepartment of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, ItalyClassical Hodgkin’s lymphoma (CHL) accounts for 10% of all lymphomas. Nodular sclerosis and mixed cellularity accounts for nearly 80% of all CHL cases. The number of mast cells in CHL correlates with poor prognosis, is significantly higher in nodular sclerosis than in other CHL subtypes, and an association between the degree of angiogenesis and the number of intratumoral mast cells has been demonstrated in CHL. Even with the best available treatment, a significant percentage of CHL patients progress or relapse after first-line therapy. 50% of patients with disease relapse achieve subsequent long-term disease control with salvage therapies. In this context, new potential therapeutic opportunities are required, and mast cells may be regarded as a new target for adjuvant treatment of CHL through the inhibition of angiogenesis and tissue remodeling and allowing the secretion of cytotoxic cytokines.https://www.frontiersin.org/articles/10.3389/fonc.2022.964573/fullclassical hodgkin’s lymphomamast cellstumor microenvironmentangiogenesisinflammatory cells |
| spellingShingle | Domenico Ribatti Roberto Tamma Tiziana Annese Tiziana Annese Giuseppe Ingravallo Giorgina Specchia Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells Frontiers in Oncology classical hodgkin’s lymphoma mast cells tumor microenvironment angiogenesis inflammatory cells |
| title | Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells |
| title_full | Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells |
| title_fullStr | Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells |
| title_full_unstemmed | Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells |
| title_short | Inflammatory microenvironment in classical Hodgkin’s lymphoma with special stress on mast cells |
| title_sort | inflammatory microenvironment in classical hodgkin s lymphoma with special stress on mast cells |
| topic | classical hodgkin’s lymphoma mast cells tumor microenvironment angiogenesis inflammatory cells |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.964573/full |
| work_keys_str_mv | AT domenicoribatti inflammatorymicroenvironmentinclassicalhodgkinslymphomawithspecialstressonmastcells AT robertotamma inflammatorymicroenvironmentinclassicalhodgkinslymphomawithspecialstressonmastcells AT tizianaannese inflammatorymicroenvironmentinclassicalhodgkinslymphomawithspecialstressonmastcells AT tizianaannese inflammatorymicroenvironmentinclassicalhodgkinslymphomawithspecialstressonmastcells AT giuseppeingravallo inflammatorymicroenvironmentinclassicalhodgkinslymphomawithspecialstressonmastcells AT giorginaspecchia inflammatorymicroenvironmentinclassicalhodgkinslymphomawithspecialstressonmastcells |