Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method

Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method

Abstract Background: Beta-cardiotoxin (β-CTX), the three-finger toxin isolated from king cobra (Ophiophagus hannah) venom, possesses β-blocker activity as indicated by its negative chronotropy and its binding property to both β-1 and β-2 adrenergic receptors and has been proposed as a novel β-block...

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Bibliographic Details
Main Authors: Tuchakorn Lertwanakarn, Montamas Suntravat, Elda E. Sanchez, Worakan Boonhoh, R. John Solaro, Beata M. Wolska, Jody L. Martin, Pieter P. de Tombe, Kittipong Tachampa
Format: Article
Language:English
Published: SciELO 2020-07-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Beta-cardiotoxin
Cytotoxicity
Cardiomyocyte
King cobra
Purification
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100319&tlng=en

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