Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control
Mitochondria: shape shifts provide clues to cellular health The health of mitochondria is important for cellular health, and is maintained by the same mechanisms that control their shape. Mitochondria continuously divide, fuse, elongate, and shrink, forming ever-changing networks inside cells. Damag...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-0434-9 |
| Summary: | Mitochondria: shape shifts provide clues to cellular health The health of mitochondria is important for cellular health, and is maintained by the same mechanisms that control their shape. Mitochondria continuously divide, fuse, elongate, and shrink, forming ever-changing networks inside cells. Damaged mitochondria produce toxic byproducts and have been implicated in neurodegenerative diseases and cancer. Although changes in mitochondrial structure are known to be related to cellular health, the detailed mechanisms are not well understood. In a review, Woong Sun and Hyo Min Cho at the Korea University College of Medicine, Seoul, detail how mitochondrial fusion, division, and recycling are controlled, what signals are used to dispose of damaged mitochondria, and how the shape-control mechanisms also regulate mitochondrial quality. This review will help us to more clearly understand the structure-function relationship of mitochondria. |
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| ISSN: | 1226-3613 2092-6413 |