Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
We analyzed present-day data in Russian and foreign literature on development of cytokine cascade in diffuse bacterial peritonitis having studied the role of cytokines in forming systemic inflammation response syndrome. It has been showed that cytokines primary regulate local protective response by...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2016-07-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/264 |
| _version_ | 1797237389689618432 |
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| author | E. E. Chepurnykh І. A. Shurygina E. S. Shaul'skaja M. G. Shurygin |
| author_facet | E. E. Chepurnykh І. A. Shurygina E. S. Shaul'skaja M. G. Shurygin |
| author_sort | E. E. Chepurnykh |
| collection | DOAJ |
| description | We analyzed present-day data in Russian and foreign literature on development of cytokine cascade in diffuse bacterial peritonitis having studied the role of cytokines in forming systemic inflammation response syndrome. It has been showed that cytokines primary regulate local protective response by forming typical inflammatory reaction with its classic local manifestations and natural anti-microbial resistance mechanisms. The main stage in the development of diffuse bacterial peritonitis is a disbalance in the system of proinflammatory cytokines and anti-inflammatory mediators; and this disbalance defines the severity of extraabdominal complications and multisystem organ failure. In the article, the markers of inflammation severity are described assisting in evaluation of the course of inflammation process and postoperative survival rate. Due to changes in immune system of the patients, it is necessary to assess complexly their immune status including cytokine profile, which in this group of patients is of diagnostic and prognostic value and needs to be further studied |
| first_indexed | 2024-03-08T12:18:41Z |
| format | Article |
| id | doaj.art-1ca5f9102a38419db3304b0b97a86583 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:59Z |
| publishDate | 2016-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-1ca5f9102a38419db3304b0b97a865832024-03-28T07:49:16ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962016-07-011417718210.12737/23029264Role of cytokines in the pathogenesis of diffuse bacterial peritonitisE. E. Chepurnykh0І. A. Shurygina1E. S. Shaul'skaja2M. G. Shurygin3Irkutsk State Medical University; Irkutsk Scientific Center of Surgery and TraumatologyIrkutsk Scientific Center of Surgery and TraumatologyIrkutsk State Medical University; Irkutsk Scientific Center of Surgery and TraumatologyIrkutsk Scientific Center of Surgery and TraumatologyWe analyzed present-day data in Russian and foreign literature on development of cytokine cascade in diffuse bacterial peritonitis having studied the role of cytokines in forming systemic inflammation response syndrome. It has been showed that cytokines primary regulate local protective response by forming typical inflammatory reaction with its classic local manifestations and natural anti-microbial resistance mechanisms. The main stage in the development of diffuse bacterial peritonitis is a disbalance in the system of proinflammatory cytokines and anti-inflammatory mediators; and this disbalance defines the severity of extraabdominal complications and multisystem organ failure. In the article, the markers of inflammation severity are described assisting in evaluation of the course of inflammation process and postoperative survival rate. Due to changes in immune system of the patients, it is necessary to assess complexly their immune status including cytokine profile, which in this group of patients is of diagnostic and prognostic value and needs to be further studiedhttps://www.actabiomedica.ru/jour/article/view/264diffuse bacterial peritonitispathogenesiscytokines |
| spellingShingle | E. E. Chepurnykh І. A. Shurygina E. S. Shaul'skaja M. G. Shurygin Role of cytokines in the pathogenesis of diffuse bacterial peritonitis Acta Biomedica Scientifica diffuse bacterial peritonitis pathogenesis cytokines |
| title | Role of cytokines in the pathogenesis of diffuse bacterial peritonitis |
| title_full | Role of cytokines in the pathogenesis of diffuse bacterial peritonitis |
| title_fullStr | Role of cytokines in the pathogenesis of diffuse bacterial peritonitis |
| title_full_unstemmed | Role of cytokines in the pathogenesis of diffuse bacterial peritonitis |
| title_short | Role of cytokines in the pathogenesis of diffuse bacterial peritonitis |
| title_sort | role of cytokines in the pathogenesis of diffuse bacterial peritonitis |
| topic | diffuse bacterial peritonitis pathogenesis cytokines |
| url | https://www.actabiomedica.ru/jour/article/view/264 |
| work_keys_str_mv | AT eechepurnykh roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis AT íashurygina roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis AT esshaulskaja roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis AT mgshurygin roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis |