Novel insights into the impact of liver inflammatory responses on primary liver cancer development
Primary liver cancers rank among the deadliest cancers worldwide and often develop in patients with chronic liver diseases in an inflammatory context. This review highlights recent reports on the mechanisms of inflammatory-mediated hepatic cell transformation that trigger the tumorigenic process (in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-03-01
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| Series: | Liver Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568423000016 |
| _version_ | 1797854446054539264 |
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| author | Yeni Ait-Ahmed Fouad Lafdil |
| author_facet | Yeni Ait-Ahmed Fouad Lafdil |
| author_sort | Yeni Ait-Ahmed |
| collection | DOAJ |
| description | Primary liver cancers rank among the deadliest cancers worldwide and often develop in patients with chronic liver diseases in an inflammatory context. This review highlights recent reports on the mechanisms of inflammatory-mediated hepatic cell transformation that trigger the tumorigenic process (initiation steps) and the impact of the immune response favoring tumor cell expansion (progression steps). Several cytokines, namely interleukin (IL)-6, IL-17, IL-1beta, and tumor necrosis factor-alpha, have been described to play a prominent role in the initiation of liver cancers. Additionally, inflammation contributes to cancer progression by favoring tumor escape from anti-tumor immune response, angiogenesis, and metastasis through tumor growth factor-beta and matrix metalloprotease upregulation. These recent studies allowed the development of novel therapeutic strategies aiming at regulating liver inflammation. These strategies are based on the use of anti-inflammatory agents, antibodies targeting immune checkpoint molecules such as programmed death ligand 1 and molecules targeting angiogenic factors, metastasis key factors, and microRNAs involved in tumor development. This review aims at summarizing the recent studies reporting different mechanisms by which the liver inflammatory responses could contribute to liver cancer development. |
| first_indexed | 2024-04-09T20:07:16Z |
| format | Article |
| id | doaj.art-1ca641d657c548d09da49dbbffa212d3 |
| institution | Directory Open Access Journal |
| issn | 2542-5684 |
| language | English |
| last_indexed | 2024-04-09T20:07:16Z |
| publishDate | 2023-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj.art-1ca641d657c548d09da49dbbffa212d32023-04-01T08:51:04ZengKeAi Communications Co., Ltd.Liver Research2542-56842023-03-01712634Novel insights into the impact of liver inflammatory responses on primary liver cancer developmentYeni Ait-Ahmed0Fouad Lafdil1Université Paris-Est, UMR-S955, UPEC, Créteil, France; Institut National de la Sante et de la Recherche Medicale (INSERM), U955, Créteil, FranceUniversité Paris-Est, UMR-S955, UPEC, Créteil, France; Institut National de la Sante et de la Recherche Medicale (INSERM), U955, Créteil, France; Institut Universitaire de France (IUF), Paris, France; Corresponding author. Université Paris-Est, UMR-S955, UPEC, Créteil, France.Primary liver cancers rank among the deadliest cancers worldwide and often develop in patients with chronic liver diseases in an inflammatory context. This review highlights recent reports on the mechanisms of inflammatory-mediated hepatic cell transformation that trigger the tumorigenic process (initiation steps) and the impact of the immune response favoring tumor cell expansion (progression steps). Several cytokines, namely interleukin (IL)-6, IL-17, IL-1beta, and tumor necrosis factor-alpha, have been described to play a prominent role in the initiation of liver cancers. Additionally, inflammation contributes to cancer progression by favoring tumor escape from anti-tumor immune response, angiogenesis, and metastasis through tumor growth factor-beta and matrix metalloprotease upregulation. These recent studies allowed the development of novel therapeutic strategies aiming at regulating liver inflammation. These strategies are based on the use of anti-inflammatory agents, antibodies targeting immune checkpoint molecules such as programmed death ligand 1 and molecules targeting angiogenic factors, metastasis key factors, and microRNAs involved in tumor development. This review aims at summarizing the recent studies reporting different mechanisms by which the liver inflammatory responses could contribute to liver cancer development.http://www.sciencedirect.com/science/article/pii/S2542568423000016Liver inflammationPrimary liver cancersCytokinesImmunotherapyMicroRNA (miRNA, miR) |
| spellingShingle | Yeni Ait-Ahmed Fouad Lafdil Novel insights into the impact of liver inflammatory responses on primary liver cancer development Liver Research Liver inflammation Primary liver cancers Cytokines Immunotherapy MicroRNA (miRNA, miR) |
| title | Novel insights into the impact of liver inflammatory responses on primary liver cancer development |
| title_full | Novel insights into the impact of liver inflammatory responses on primary liver cancer development |
| title_fullStr | Novel insights into the impact of liver inflammatory responses on primary liver cancer development |
| title_full_unstemmed | Novel insights into the impact of liver inflammatory responses on primary liver cancer development |
| title_short | Novel insights into the impact of liver inflammatory responses on primary liver cancer development |
| title_sort | novel insights into the impact of liver inflammatory responses on primary liver cancer development |
| topic | Liver inflammation Primary liver cancers Cytokines Immunotherapy MicroRNA (miRNA, miR) |
| url | http://www.sciencedirect.com/science/article/pii/S2542568423000016 |
| work_keys_str_mv | AT yeniaitahmed novelinsightsintotheimpactofliverinflammatoryresponsesonprimarylivercancerdevelopment AT fouadlafdil novelinsightsintotheimpactofliverinflammatoryresponsesonprimarylivercancerdevelopment |