The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub>
Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/2/1043 |
| Summary: | Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the expression of MMP-2 and MMP-9, thus causing the degradation of the extracellular matrix, an increase in the ROS H<sub>2</sub>O<sub>2</sub> might have an impact on MMP-2/MMP-9 activity. The natural compound curcumin has shown some anticancer effects, although its bioavailability hinders its therapeutic potential. However, curcumin and its analogues were shown to resensitize kidney cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. This study shows that the curcuminoid EF24 in combination with TRAIL increases peroxidase activity in the renal adenocarcinoma cell line ACHN, reducing the level of intracellular H<sub>2</sub>O<sub>2</sub> and MMP-2/MMP-9 activity, a mechanism that is also observed after treatment with curcumin and TRAIL. |
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| ISSN: | 1661-6596 1422-0067 |