The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub>
Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1043 |
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| author | Verónica Ibáñez Gaspar Tara McMorrow |
| author_facet | Verónica Ibáñez Gaspar Tara McMorrow |
| author_sort | Verónica Ibáñez Gaspar |
| collection | DOAJ |
| description | Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the expression of MMP-2 and MMP-9, thus causing the degradation of the extracellular matrix, an increase in the ROS H<sub>2</sub>O<sub>2</sub> might have an impact on MMP-2/MMP-9 activity. The natural compound curcumin has shown some anticancer effects, although its bioavailability hinders its therapeutic potential. However, curcumin and its analogues were shown to resensitize kidney cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. This study shows that the curcuminoid EF24 in combination with TRAIL increases peroxidase activity in the renal adenocarcinoma cell line ACHN, reducing the level of intracellular H<sub>2</sub>O<sub>2</sub> and MMP-2/MMP-9 activity, a mechanism that is also observed after treatment with curcumin and TRAIL. |
| first_indexed | 2024-03-09T12:26:28Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:26:28Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1ca6524eba59417a8e68cb333694f0032023-11-30T22:34:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242104310.3390/ijms24021043The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub>Verónica Ibáñez Gaspar0Tara McMorrow1UCD Centre for Toxicology, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, 4 Dublin, IrelandUCD Centre for Toxicology, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, 4 Dublin, IrelandCancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the expression of MMP-2 and MMP-9, thus causing the degradation of the extracellular matrix, an increase in the ROS H<sub>2</sub>O<sub>2</sub> might have an impact on MMP-2/MMP-9 activity. The natural compound curcumin has shown some anticancer effects, although its bioavailability hinders its therapeutic potential. However, curcumin and its analogues were shown to resensitize kidney cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. This study shows that the curcuminoid EF24 in combination with TRAIL increases peroxidase activity in the renal adenocarcinoma cell line ACHN, reducing the level of intracellular H<sub>2</sub>O<sub>2</sub> and MMP-2/MMP-9 activity, a mechanism that is also observed after treatment with curcumin and TRAIL.https://www.mdpi.com/1422-0067/24/2/1043curcuminDMCEF24H<sub>2</sub>O<sub>2</sub>kidney cancerMMP |
| spellingShingle | Verónica Ibáñez Gaspar Tara McMorrow The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub> International Journal of Molecular Sciences curcumin DMC EF24 H<sub>2</sub>O<sub>2</sub> kidney cancer MMP |
| title | The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub> |
| title_full | The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub> |
| title_fullStr | The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub> |
| title_full_unstemmed | The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub> |
| title_short | The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H<sub>2</sub>O<sub>2</sub> |
| title_sort | curcuminoid ef24 in combination with trail reduces human renal cancer cell migration by decreasing mmp 2 mmp 9 activity through a reduction in h sub 2 sub o sub 2 sub |
| topic | curcumin DMC EF24 H<sub>2</sub>O<sub>2</sub> kidney cancer MMP |
| url | https://www.mdpi.com/1422-0067/24/2/1043 |
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