Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance
As a nutrient, heme is important for various cellular processes of organism. Bacteria can obtain heme via heme biosynthesis or/and uptake of exogenous heme from the host. On the other side, absorption of excess heme is cytotoxic to bacteria. Thus, bacteria have developed systems to relieve heme toxi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023054415 |
| _version_ | 1797771411641597952 |
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| author | Mengying Wang Yuwei Wang Mingshu Wang Mafeng Liu Anchun Cheng |
| author_facet | Mengying Wang Yuwei Wang Mingshu Wang Mafeng Liu Anchun Cheng |
| author_sort | Mengying Wang |
| collection | DOAJ |
| description | As a nutrient, heme is important for various cellular processes of organism. Bacteria can obtain heme via heme biosynthesis or/and uptake of exogenous heme from the host. On the other side, absorption of excess heme is cytotoxic to bacteria. Thus, bacteria have developed systems to relieve heme toxicity and contribute to the maintenance of heme homeostasis. In the past decades, the mechanisms underlying heme acquisition and tolerance have been well studied in Gram-positive model bacteria, such as Staphylococcus, Streptococcus and other Gram-positive bacteria. Here, we review the elaborate mechanisms by which these bacteria acquire heme and resist heme toxicity. Since both the heme utilization system and the heme tolerance system contribute to bacterial virulence, this review is not only helpful for a comprehensive understanding of the heme homeostasis mechanism in Gram-positive bacteria but also provides a theoretical basis for the development of antimicrobial agents. |
| first_indexed | 2024-03-12T21:36:10Z |
| format | Article |
| id | doaj.art-1ca70136da0543c098a05b2e5cbe5f37 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T21:36:10Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1ca70136da0543c098a05b2e5cbe5f372023-07-27T05:59:00ZengElsevierHeliyon2405-84402023-07-0197e18233Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balanceMengying Wang0Yuwei Wang1Mingshu Wang2Mafeng Liu3Anchun Cheng4Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaMianyang Academy of Agricultural Sciences, Institute of Livestock Research, Mianyang 621023, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; Corresponding author. Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China.Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China; Corresponding author. Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China.As a nutrient, heme is important for various cellular processes of organism. Bacteria can obtain heme via heme biosynthesis or/and uptake of exogenous heme from the host. On the other side, absorption of excess heme is cytotoxic to bacteria. Thus, bacteria have developed systems to relieve heme toxicity and contribute to the maintenance of heme homeostasis. In the past decades, the mechanisms underlying heme acquisition and tolerance have been well studied in Gram-positive model bacteria, such as Staphylococcus, Streptococcus and other Gram-positive bacteria. Here, we review the elaborate mechanisms by which these bacteria acquire heme and resist heme toxicity. Since both the heme utilization system and the heme tolerance system contribute to bacterial virulence, this review is not only helpful for a comprehensive understanding of the heme homeostasis mechanism in Gram-positive bacteria but also provides a theoretical basis for the development of antimicrobial agents.http://www.sciencedirect.com/science/article/pii/S2405844023054415Heme utilizationHeme toleranceGram-positive bacteria |
| spellingShingle | Mengying Wang Yuwei Wang Mingshu Wang Mafeng Liu Anchun Cheng Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance Heliyon Heme utilization Heme tolerance Gram-positive bacteria |
| title | Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance |
| title_full | Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance |
| title_fullStr | Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance |
| title_full_unstemmed | Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance |
| title_short | Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance |
| title_sort | heme acquisition and tolerance in gram positive model bacteria an orchestrated balance |
| topic | Heme utilization Heme tolerance Gram-positive bacteria |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023054415 |
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