Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics

Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics

Abstract Background Specific microRNAs (miRNAs) play essential roles in airway remodeling in asthma. Infection with influenza A virus (IAV) may also magnify pre-existing airway remodeling leading to asthma exacerbation. However, these events remain to be fully defined. We investigated the expression...

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Bibliographic Details
Main Authors: Fatemeh Moheimani, Jorinke Koops, Teresa Williams, Andrew T. Reid, Philip M. Hansbro, Peter A. Wark, Darryl A. Knight
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Respiratory Research
Subjects:
Severe asthma
Epithelial cells
microRNA
Influenza A virus
Airway remodeling
Online Access:http://link.springer.com/article/10.1186/s12931-018-0851-7

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