The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial
Background: Oral and saliva conditions of patients undergoing chemotherapy is often affected by the medication they receive. Up to now, no appropriate medication that possesses the positive effects of chemotherapy without presenting oral complications has been introduced. Objective: The aim of th...
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| Format: | Article |
| Language: | English |
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Electronic Physician
2015-11-01
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| Series: | Electronic Physician |
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700902/ |
| _version_ | 1828305345677623296 |
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| author | Sepideh Banava Mohammad Houshyari Tahmineh Safaie |
| author_facet | Sepideh Banava Mohammad Houshyari Tahmineh Safaie |
| author_sort | Sepideh Banava |
| collection | DOAJ |
| description | Background: Oral and saliva conditions of patients undergoing chemotherapy is often affected by the medication
they receive. Up to now, no appropriate medication that possesses the positive effects of chemotherapy without
presenting oral complications has been introduced.
Objective: The aim of this study was to assess the clinical effects of CPP-ACPF paste on the oral and salivary
status of patients undergoing chemotherapy.
Methods: From October 2013 to April 2014, 20 patients in chemotherapy treatment plans and who met the
inclusion criteria enrolled in this randomized parallel single-blind controlled clinical trial in Shohada-e-Tajrish
Hospital in Tehran, Iran. Patients were divided into two groups: 1) patients received their daily medication of
cancer therapy center (group 1, control); 2) patients applied CPP-ACPF Crème (MI paste plus, GC USA) twice a
day as instructed (group 2). The baseline status of oral conditions of patients (mucositis, dry mouth, infection,
diminished tasting sense, difficulty in food intake, burning sensation of mucosa, saliva and dental plaque pH, rest
and stimulated saliva, buffering capacity of saliva) were recorded and reevaluated after 21 and 42 days. The data
were analyzed with a Mann-Whitney U-test.
Results: A total of 20 patients were allocated randomly to groups 1 and 2. The Mann-Whitney U-test showed that
application of CPP-ACPF paste twice daily did not cause any significant difference in oral complication of the
subject group compared with the control group (p>0.05). Among salivary signs, resting and stimulated saliva
rates and saliva buffering capacity had significantly altered in the CPP-ACPF group in day 21 and 42 in
comparison with those of the control group (p<0.05).
Conclusion: Application of CPP-ACPF paste before and during chemotherapy can improve the salivary status of
patients undergoing this treatment.
Trial registration: The trial is registered at the U.S. National Institutes of Health (https://www.clinicaltrials.gov)
with the identification number NCT01737307.
Funding: The authors received no financial support for the research, authorship, and/or publication of this article |
| first_indexed | 2024-04-13T14:28:09Z |
| format | Article |
| id | doaj.art-1cac22a0162747849ecd61db73fd931d |
| institution | Directory Open Access Journal |
| issn | 2008-5842 2008-5842 |
| language | English |
| last_indexed | 2024-04-13T14:28:09Z |
| publishDate | 2015-11-01 |
| publisher | Electronic Physician |
| record_format | Article |
| series | Electronic Physician |
| spelling | doaj.art-1cac22a0162747849ecd61db73fd931d2022-12-22T02:43:16ZengElectronic PhysicianElectronic Physician2008-58422008-58422015-11-01771535154110.19082/1535The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trialSepideh BanavaMohammad HoushyariTahmineh SafaieBackground: Oral and saliva conditions of patients undergoing chemotherapy is often affected by the medication they receive. Up to now, no appropriate medication that possesses the positive effects of chemotherapy without presenting oral complications has been introduced. Objective: The aim of this study was to assess the clinical effects of CPP-ACPF paste on the oral and salivary status of patients undergoing chemotherapy. Methods: From October 2013 to April 2014, 20 patients in chemotherapy treatment plans and who met the inclusion criteria enrolled in this randomized parallel single-blind controlled clinical trial in Shohada-e-Tajrish Hospital in Tehran, Iran. Patients were divided into two groups: 1) patients received their daily medication of cancer therapy center (group 1, control); 2) patients applied CPP-ACPF Crème (MI paste plus, GC USA) twice a day as instructed (group 2). The baseline status of oral conditions of patients (mucositis, dry mouth, infection, diminished tasting sense, difficulty in food intake, burning sensation of mucosa, saliva and dental plaque pH, rest and stimulated saliva, buffering capacity of saliva) were recorded and reevaluated after 21 and 42 days. The data were analyzed with a Mann-Whitney U-test. Results: A total of 20 patients were allocated randomly to groups 1 and 2. The Mann-Whitney U-test showed that application of CPP-ACPF paste twice daily did not cause any significant difference in oral complication of the subject group compared with the control group (p>0.05). Among salivary signs, resting and stimulated saliva rates and saliva buffering capacity had significantly altered in the CPP-ACPF group in day 21 and 42 in comparison with those of the control group (p<0.05). Conclusion: Application of CPP-ACPF paste before and during chemotherapy can improve the salivary status of patients undergoing this treatment. Trial registration: The trial is registered at the U.S. National Institutes of Health (https://www.clinicaltrials.gov) with the identification number NCT01737307. Funding: The authors received no financial support for the research, authorship, and/or publication of this articlehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700902/Oral complicationdental plaquesaliva |
| spellingShingle | Sepideh Banava Mohammad Houshyari Tahmineh Safaie The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial Electronic Physician Oral complication dental plaque saliva |
| title | The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial |
| title_full | The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial |
| title_fullStr | The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial |
| title_full_unstemmed | The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial |
| title_short | The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy: A randomized controlled clinical trial |
| title_sort | effect of casein phosphopeptide amorphous calcium phosphate fluoride paste cpp acpf on oral and salivary conditions of patients undergoing chemotherapy a randomized controlled clinical trial |
| topic | Oral complication dental plaque saliva |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700902/ |
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