The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease
Introduction:Pregnancy is considered a low-grade inflammatory state presented with increased levels of pro-inflammatory markers. Despite the well-recognized association between inflammation and kidney injury, there is still a lack of available data concerning the role of thyroid hormone alterations...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-05-01
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| Series: | İstanbul Medical Journal |
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| Online Access: |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/the-relationship-of-kidney-njury-molecule-1-and-nt/52041
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| _version_ | 1797915858219040768 |
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| author | Emel Sağlam Bennur Esen Saadet Pilten Vüsale Gözütok Ahmet Engin Atay |
| author_facet | Emel Sağlam Bennur Esen Saadet Pilten Vüsale Gözütok Ahmet Engin Atay |
| author_sort | Emel Sağlam |
| collection | DOAJ |
| description | Introduction:Pregnancy is considered a low-grade inflammatory state presented with increased levels of pro-inflammatory markers. Despite the well-recognized association between inflammation and kidney injury, there is still a lack of available data concerning the role of thyroid hormone alterations in inflammation and acute kidney injury (AKI). We examined the relationship of kidney injury molecule-1 (KIM-1) and interleukin-1 beta (IL-1β) with renal and hepatic injury in hypothyroid, normothyroid (euthyroid), or hyperthyroid pregnant women.Methods:A total of 77 pregnant women with no additional health problems were enrolled in the study. Serum KIM-1 and IL-1β levels were analyzed by ELISA.Results:There were significant differences between normothyroid, hyperthyroid, and hypothyroid pregnants regarding creatinine, aspartate aminotransferase (AST), free T4, anti-thyroglobulin (anti-TG), anti-thyroperoxidase (anti-TPO), and plateletcrit (PCT) levels (p=0.018, p=0.032, p=0.011, p=0.001, p=0.003, and p=0.016, respectively). The mean creatinine levels of the hypothyroid group were significantly higher than those of the hyperthyroid group (p=0.015). The mean AST and PCT levels of the hypothyroid group were considerably higher than those of the normothyroid group (p=0.024 and p=0.014, respectively). In the correlation analysis, age was the single parameter that was significantly correlated with KIM-1 and IL-1β in all pregnant women (p=-0.024 and p=-0.018, respectively). In the hypothyroid pregnant women group, KIM-1 was correlated with creatinine levels and age (p=0.037 and p=0.022, respectively).Conclusion:KIM-1 level in pregnant women with hypothyroidism can serve as a useful biomarker to show AKI. |
| first_indexed | 2024-04-10T12:48:07Z |
| format | Article |
| id | doaj.art-1caec138ad444c609c5c125fb6396a32 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T12:48:07Z |
| publishDate | 2022-05-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-1caec138ad444c609c5c125fb6396a322023-02-15T16:13:55ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2022-05-01232858910.4274/imj.galenos.2022.4754213049054The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid DiseaseEmel Sağlam0Bennur Esen1Saadet Pilten2Vüsale Gözütok3Ahmet Engin Atay4 University of Health Sciences Turkey, Bağcılar Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey Acıbadem Mehmet Ali Aydınlar University Hospital, Clinic of Nephrology and Internal Medicine, İstanbul, Turkey University of Health Sciences Turkey, Bağcılar Training and Research Hospital, Clinic of Biochemistry, İstanbul, Turkey University of Health Sciences Turkey, Bağcılar Training and Research Hospital, Clinic of Family Medicine, İstanbul, Turkey University of Health Sciences Turkey, Bağcılar Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey Introduction:Pregnancy is considered a low-grade inflammatory state presented with increased levels of pro-inflammatory markers. Despite the well-recognized association between inflammation and kidney injury, there is still a lack of available data concerning the role of thyroid hormone alterations in inflammation and acute kidney injury (AKI). We examined the relationship of kidney injury molecule-1 (KIM-1) and interleukin-1 beta (IL-1β) with renal and hepatic injury in hypothyroid, normothyroid (euthyroid), or hyperthyroid pregnant women.Methods:A total of 77 pregnant women with no additional health problems were enrolled in the study. Serum KIM-1 and IL-1β levels were analyzed by ELISA.Results:There were significant differences between normothyroid, hyperthyroid, and hypothyroid pregnants regarding creatinine, aspartate aminotransferase (AST), free T4, anti-thyroglobulin (anti-TG), anti-thyroperoxidase (anti-TPO), and plateletcrit (PCT) levels (p=0.018, p=0.032, p=0.011, p=0.001, p=0.003, and p=0.016, respectively). The mean creatinine levels of the hypothyroid group were significantly higher than those of the hyperthyroid group (p=0.015). The mean AST and PCT levels of the hypothyroid group were considerably higher than those of the normothyroid group (p=0.024 and p=0.014, respectively). In the correlation analysis, age was the single parameter that was significantly correlated with KIM-1 and IL-1β in all pregnant women (p=-0.024 and p=-0.018, respectively). In the hypothyroid pregnant women group, KIM-1 was correlated with creatinine levels and age (p=0.037 and p=0.022, respectively).Conclusion:KIM-1 level in pregnant women with hypothyroidism can serve as a useful biomarker to show AKI. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/the-relationship-of-kidney-njury-molecule-1-and-nt/52041 interleukinskidney injury molecule-1pregnancythyroid dysfunction |
| spellingShingle | Emel Sağlam Bennur Esen Saadet Pilten Vüsale Gözütok Ahmet Engin Atay The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease İstanbul Medical Journal interleukins kidney injury molecule-1 pregnancy thyroid dysfunction |
| title | The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease |
| title_full | The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease |
| title_fullStr | The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease |
| title_full_unstemmed | The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease |
| title_short | The Relationship of Kidney Injury Molecule-1 and Interleukin-1 Beta with Hepatic and Renal Functions in Pregnant Women with Thyroid Disease |
| title_sort | relationship of kidney injury molecule 1 and interleukin 1 beta with hepatic and renal functions in pregnant women with thyroid disease |
| topic | interleukins kidney injury molecule-1 pregnancy thyroid dysfunction |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/the-relationship-of-kidney-njury-molecule-1-and-nt/52041
|
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