Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study
Abstract Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 w...
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-55316-x |
| _version_ | 1797274915105144832 |
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| author | Nina Sophia Decker Theron Johnson Charlotte Le Cornet Sabine Behrens Nadia Obi Rudolf Kaaks Jenny Chang-Claude Renée Turzanski Fortner |
| author_facet | Nina Sophia Decker Theron Johnson Charlotte Le Cornet Sabine Behrens Nadia Obi Rudolf Kaaks Jenny Chang-Claude Renée Turzanski Fortner |
| author_sort | Nina Sophia Decker |
| collection | DOAJ |
| description | Abstract Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5–24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (− 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations. |
| first_indexed | 2024-03-07T15:05:55Z |
| format | Article |
| id | doaj.art-1caee2f199f545c2936a52a7f3e79392 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:05:55Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1caee2f199f545c2936a52a7f3e793922024-03-05T18:53:58ZengNature PortfolioScientific Reports2045-23222024-02-0114111610.1038/s41598-024-55316-xAssociations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional studyNina Sophia Decker0Theron Johnson1Charlotte Le Cornet2Sabine Behrens3Nadia Obi4Rudolf Kaaks5Jenny Chang-Claude6Renée Turzanski Fortner7Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-EppendorfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Abstract Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5–24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (− 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations.https://doi.org/10.1038/s41598-024-55316-x |
| spellingShingle | Nina Sophia Decker Theron Johnson Charlotte Le Cornet Sabine Behrens Nadia Obi Rudolf Kaaks Jenny Chang-Claude Renée Turzanski Fortner Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study Scientific Reports |
| title | Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study |
| title_full | Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study |
| title_fullStr | Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study |
| title_full_unstemmed | Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study |
| title_short | Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study |
| title_sort | associations between lifestyle health and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer a cross sectional study |
| url | https://doi.org/10.1038/s41598-024-55316-x |
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