New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer tran...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/6/776 |
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| author | Dominga Iacobazzi Paolo Convertini Simona Todisco Anna Santarsiero Vito Iacobazzi Vittoria Infantino |
| author_facet | Dominga Iacobazzi Paolo Convertini Simona Todisco Anna Santarsiero Vito Iacobazzi Vittoria Infantino |
| author_sort | Dominga Iacobazzi |
| collection | DOAJ |
| description | The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer translocation into the nucleus. A complex crosstalk between NF-κB signaling and metabolism is emerging in innate immunity. Metabolic enzymes and metabolites regulate NF-κB activity in many cases through post-translational modifications such as acetylation and phosphorylation. On the other hand, NF-κB affects immunometabolic pathways, including the citrate pathway, thereby building an intricate network. In this review, the emerging findings about NF-κB function in innate immunity and the interplay between NF-κB and immunometabolism have been discussed. These outcomes allow for a deeper comprehension of the molecular mechanisms underlying NF-κB function in innate immune cells. Moreover, the new insights are important in order to perceive NF-κB signaling as a potential therapeutic target for inflammatory/immune chronic diseases. |
| first_indexed | 2024-03-11T02:45:27Z |
| format | Article |
| id | doaj.art-1caf4cfb16904335b5d8d5571ee141d1 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T02:45:27Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-1caf4cfb16904335b5d8d5571ee141d12023-11-18T09:22:25ZengMDPI AGBiology2079-77372023-05-0112677610.3390/biology12060776New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic CrosstalksDominga Iacobazzi0Paolo Convertini1Simona Todisco2Anna Santarsiero3Vito Iacobazzi4Vittoria Infantino5Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol BS2 8HW, UKDepartment of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDepartment of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDepartment of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, ItalyDepartment of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyThe nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation. Two main pathways—canonical and non-canonical—are responsible for NF-κB activation and heterodimer translocation into the nucleus. A complex crosstalk between NF-κB signaling and metabolism is emerging in innate immunity. Metabolic enzymes and metabolites regulate NF-κB activity in many cases through post-translational modifications such as acetylation and phosphorylation. On the other hand, NF-κB affects immunometabolic pathways, including the citrate pathway, thereby building an intricate network. In this review, the emerging findings about NF-κB function in innate immunity and the interplay between NF-κB and immunometabolism have been discussed. These outcomes allow for a deeper comprehension of the molecular mechanisms underlying NF-κB function in innate immune cells. Moreover, the new insights are important in order to perceive NF-κB signaling as a potential therapeutic target for inflammatory/immune chronic diseases.https://www.mdpi.com/2079-7737/12/6/776NF-κBinnate immunitymacrophagesimmunometabolismgene expression |
| spellingShingle | Dominga Iacobazzi Paolo Convertini Simona Todisco Anna Santarsiero Vito Iacobazzi Vittoria Infantino New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks Biology NF-κB innate immunity macrophages immunometabolism gene expression |
| title | New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks |
| title_full | New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks |
| title_fullStr | New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks |
| title_full_unstemmed | New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks |
| title_short | New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks |
| title_sort | new insights into nf κb signaling in innate immunity focus on immunometabolic crosstalks |
| topic | NF-κB innate immunity macrophages immunometabolism gene expression |
| url | https://www.mdpi.com/2079-7737/12/6/776 |
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