Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons

Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons

Glial progenitor cells are widely distributed in brain parenchyma and represent a suitable target for future therapeutic interventions that generate new neurons via in situ reprogramming. Previous studies have shown successful reprogramming of mouse glia into neurons whereas the conversion of human...

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Bibliographic Details
Main Authors: Jessica Giacomoni, Andreas Bruzelius, Christina-Anastasia Stamouli, Daniella Rylander Ottosson
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
human embryonic stem cells
neurological disorders
PDGFRα
GFAP
cellular reprogramming
induced neurons
Online Access:https://www.mdpi.com/2073-4409/9/11/2451

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