Structural Insights Into the Transcriptional Regulation of HigBA Toxin–Antitoxin System by Antitoxin HigA in Pseudomonas aeruginosa

Structural Insights Into the Transcriptional Regulation of HigBA Toxin–Antitoxin System by Antitoxin HigA in Pseudomonas aeruginosa

HigB-HigA is a bacterial toxin–antitoxin (TA) system in which the antitoxin HigA can mask the endoribonuclease activity of toxin HigB and repress the transcription of the TA operon by binding to its own promoter region. The opportunistic pathogen Pseudomonas aeruginosa HigBA (PaHigBA) is closely ass...

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Bibliographic Details
Main Authors: Ying Liu, Zengqiang Gao, Guangfeng Liu, Zhi Geng, Yuhui Dong, Heng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
toxin–antitoxin system
HigB-HigA
transcription regulator
crystal structure
DNA-binding protein
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03158/full

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