Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats
Objective: To evaluate the antidiabetic and hypolipidemic activity of aqueous root extract of Icacina senegalensis (I. senegalensis) in alloxan-induced diabetic rats. Method: Blood glucose levels of alloxan-induced diabetic rats were monitored after the administration of I. senegalensis extract (100...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221618914600251 |
| _version_ | 1828838824169439232 |
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| author | GC Akuodor PM Udia A Bassey KC Chilaka OA Okezie |
| author_facet | GC Akuodor PM Udia A Bassey KC Chilaka OA Okezie |
| author_sort | GC Akuodor |
| collection | DOAJ |
| description | Objective: To evaluate the antidiabetic and hypolipidemic activity of aqueous root extract of Icacina senegalensis (I. senegalensis) in alloxan-induced diabetic rats.
Method: Blood glucose levels of alloxan-induced diabetic rats were monitored after the administration of I. senegalensis extract (100, 200 and 400 mg/kg) to diabetic rats for 14 d. Different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also examined.
Results: Treatment of alloxan diabetic rats with the extract showed significant (P<0.05) activity. The activity of the extract was comparable to that of the standard drug, glinbeclamide.
Conclusions: The results suggest that the root extract of I. senegalensis possesses antidiabetic and hypolipidemic properties, which might be a potential source for isolation of new orally active agent in the treatment of diabetes and its associated complications. |
| first_indexed | 2024-12-12T19:10:52Z |
| format | Article |
| id | doaj.art-1cb49eb7b9414e9d93491260bf275ade |
| institution | Directory Open Access Journal |
| issn | 2221-6189 |
| language | English |
| last_indexed | 2024-12-12T19:10:52Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-1cb49eb7b9414e9d93491260bf275ade2022-12-22T00:14:51ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892014-01-01329910310.1016/S2221-6189(14)60025-1Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic ratsGC Akuodor0PM Udia1A Bassey2KC Chilaka3OA Okezie4Department of Pharmacology, College of Medical Sciences, University of Calabar, NigeriaDepartment of Pharmacology, College of Medical Sciences, University of Calabar, NigeriaDepartment of Pharmacology, College of Health Sciences, University of Uyo, NigeriaDepartment of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Awka, NigeriaDepartment of Chemical Pathology, Federal Teaching Hospital, Abakaliki, NigeriaObjective: To evaluate the antidiabetic and hypolipidemic activity of aqueous root extract of Icacina senegalensis (I. senegalensis) in alloxan-induced diabetic rats. Method: Blood glucose levels of alloxan-induced diabetic rats were monitored after the administration of I. senegalensis extract (100, 200 and 400 mg/kg) to diabetic rats for 14 d. Different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also examined. Results: Treatment of alloxan diabetic rats with the extract showed significant (P<0.05) activity. The activity of the extract was comparable to that of the standard drug, glinbeclamide. Conclusions: The results suggest that the root extract of I. senegalensis possesses antidiabetic and hypolipidemic properties, which might be a potential source for isolation of new orally active agent in the treatment of diabetes and its associated complications.http://www.sciencedirect.com/science/article/pii/S2221618914600251DiabetesAlloxanIcacina senegalensisLipid profileRats |
| spellingShingle | GC Akuodor PM Udia A Bassey KC Chilaka OA Okezie Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats Journal of Acute Disease Diabetes Alloxan Icacina senegalensis Lipid profile Rats |
| title | Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats |
| title_full | Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats |
| title_fullStr | Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats |
| title_full_unstemmed | Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats |
| title_short | Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats |
| title_sort | antihyperglycemic and antihyperlipidemic properties of aqueous root extract of icacina senegalensis in alloxan induced diabetic rats |
| topic | Diabetes Alloxan Icacina senegalensis Lipid profile Rats |
| url | http://www.sciencedirect.com/science/article/pii/S2221618914600251 |
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