ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems
The grafting of poly(hydroxyethylmethacrylate) on polymeric porous membranes via atom transfer radical polymerization (ATRP) and subsequent modification with a photo-responsive spiropyran derivative is described. This method leads to photo-responsive membranes with desirable properties such as light...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2015-06-01
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Series: | Science and Technology of Advanced Materials |
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Online Access: | http://dx.doi.org/10.1088/1468-6996/16/3/034604 |
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author | Anja C Pauly Katrin Schöller Lukas Baumann René M Rossi Kathrin Dustmann Ulrich Ziener Damien de Courten Martin Wolf Luciano F Boesel Lukas J Scherer |
author_facet | Anja C Pauly Katrin Schöller Lukas Baumann René M Rossi Kathrin Dustmann Ulrich Ziener Damien de Courten Martin Wolf Luciano F Boesel Lukas J Scherer |
author_sort | Anja C Pauly |
collection | DOAJ |
description | The grafting of poly(hydroxyethylmethacrylate) on polymeric porous membranes via atom transfer radical polymerization (ATRP) and subsequent modification with a photo-responsive spiropyran derivative is described. This method leads to photo-responsive membranes with desirable properties such as light-controlled permeability changes, exceptional photo-stability and repeatability of the photo-responsive switching. Conventional track etched polyester membranes were first treated with plasma polymer coating introducing anchoring groups, which allowed the attachment of ATRP-initiator molecules on the membrane surface. Surface initiated ARGET–ATRP of hydroxyethylmethacrylate (where ARGET stands for activator regenerated by electron transfer) leads to a membrane covered with a polymer layer, whereas the controlled polymerization procedure allows good control over the thickness of the polymer layer in respect to the polymerization conditions. Therefore, the final permeability of the membranes could be tailored by choice of pore diameter of the initial membranes, applied monomer concentration or polymerization time. Moreover a remarkable switch in permeability (more than 1000%) upon irradiation with UV-light could be achieved. These properties enable possible applications in the field of transdermal drug delivery, filtration, or sensing. |
first_indexed | 2024-04-12T09:10:06Z |
format | Article |
id | doaj.art-1cb55139a00e4b3b8ceeddbbff7d7f69 |
institution | Directory Open Access Journal |
issn | 1468-6996 1878-5514 |
language | English |
last_indexed | 2024-04-12T09:10:06Z |
publishDate | 2015-06-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | Science and Technology of Advanced Materials |
spelling | doaj.art-1cb55139a00e4b3b8ceeddbbff7d7f692022-12-22T03:38:59ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142015-06-0116310.1088/1468-6996/16/3/03460411661286ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systemsAnja C Pauly0Katrin Schöller1Lukas Baumann2René M Rossi3Kathrin Dustmann4Ulrich Ziener5Damien de Courten6Martin Wolf7Luciano F Boesel8Lukas J Scherer9Laboratory for Protection and PhysiologyLaboratory for Protection and PhysiologyLaboratory for Protection and PhysiologyLaboratory for Protection and PhysiologyLaboratory for Protection and PhysiologyUlm University, Institute of Organic Chemistry III, Macromolecular Chemistry and Organic MaterialsUniversity Hospital ZürichUniversity Hospital ZürichLaboratory for Protection and PhysiologyLaboratory for Protection and PhysiologyThe grafting of poly(hydroxyethylmethacrylate) on polymeric porous membranes via atom transfer radical polymerization (ATRP) and subsequent modification with a photo-responsive spiropyran derivative is described. This method leads to photo-responsive membranes with desirable properties such as light-controlled permeability changes, exceptional photo-stability and repeatability of the photo-responsive switching. Conventional track etched polyester membranes were first treated with plasma polymer coating introducing anchoring groups, which allowed the attachment of ATRP-initiator molecules on the membrane surface. Surface initiated ARGET–ATRP of hydroxyethylmethacrylate (where ARGET stands for activator regenerated by electron transfer) leads to a membrane covered with a polymer layer, whereas the controlled polymerization procedure allows good control over the thickness of the polymer layer in respect to the polymerization conditions. Therefore, the final permeability of the membranes could be tailored by choice of pore diameter of the initial membranes, applied monomer concentration or polymerization time. Moreover a remarkable switch in permeability (more than 1000%) upon irradiation with UV-light could be achieved. These properties enable possible applications in the field of transdermal drug delivery, filtration, or sensing.http://dx.doi.org/10.1088/1468-6996/16/3/034604light-responsive materialsmembranesarget–atrpsurface initiated polymerizationdrug delivery |
spellingShingle | Anja C Pauly Katrin Schöller Lukas Baumann René M Rossi Kathrin Dustmann Ulrich Ziener Damien de Courten Martin Wolf Luciano F Boesel Lukas J Scherer ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems Science and Technology of Advanced Materials light-responsive materials membranes arget–atrp surface initiated polymerization drug delivery |
title | ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems |
title_full | ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems |
title_fullStr | ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems |
title_full_unstemmed | ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems |
title_short | ATRP-based synthesis and characterization of light-responsive coatings for transdermal delivery systems |
title_sort | atrp based synthesis and characterization of light responsive coatings for transdermal delivery systems |
topic | light-responsive materials membranes arget–atrp surface initiated polymerization drug delivery |
url | http://dx.doi.org/10.1088/1468-6996/16/3/034604 |
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