Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings
Background: Primary sarcoma of the prostate is extremely rare and accounts for 0.1% of all prostate cancers. This type of cancer is associated with poor prognosis due to aggressive biological behavior. The World Health Organization histologically classified prostate sarcomas as stromal tumor of unkn...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Urology Annals |
| Subjects: | |
| Online Access: | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=1;spage=115;epage=119;aulast=Öztürk |
| _version_ | 1818563323147321344 |
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| author | Hakan Öztürk |
| author_facet | Hakan Öztürk |
| author_sort | Hakan Öztürk |
| collection | DOAJ |
| description | Background: Primary sarcoma of the prostate is extremely rare and accounts for 0.1% of all prostate cancers. This type of cancer is associated with poor prognosis due to aggressive biological behavior. The World Health Organization histologically classified prostate sarcomas as stromal tumor of unknown malignant potential (STUMP) and stromal sarcoma.
Patients and Methods: A 39-year-old patient presented with lower urinary tract symptoms over the last few months. On digital rectal examination, the right lobe of the prostate was diffusely hard on palpation. Prostate-specific antigen was 0.5 ng/ml. A biopsy specimen was obtained with the guidance of transrectal ultrasonography. Immunohistochemical examination revealed positive staining for vimentin, actin, and desmin.
Results: 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography scans obtained for staging purposes with the diagnosis of primary spindle cell carcinoma of the prostate revealed widespread lung and liver metastases. A doxorubicin-based systemic chemotherapy (CTx) was initiated.
Conclusion: Spindle sarcomas of the prostate have quite aggressive nature and they have high potential to metastase. Average life expectancy is <1 year and the prognosis is poor. CTx and radiation therapy can′t yield curative effects due to poor differentiation. |
| first_indexed | 2024-12-14T01:15:10Z |
| format | Article |
| id | doaj.art-1cb67b73b2124c9e9b83f45a8c690b00 |
| institution | Directory Open Access Journal |
| issn | 0974-7796 0974-7834 |
| language | English |
| last_indexed | 2024-12-14T01:15:10Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Urology Annals |
| spelling | doaj.art-1cb67b73b2124c9e9b83f45a8c690b002022-12-21T23:22:36ZengWolters Kluwer Medknow PublicationsUrology Annals0974-77960974-78342015-01-017111511910.4103/0974-7796.148657Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findingsHakan ÖztürkBackground: Primary sarcoma of the prostate is extremely rare and accounts for 0.1% of all prostate cancers. This type of cancer is associated with poor prognosis due to aggressive biological behavior. The World Health Organization histologically classified prostate sarcomas as stromal tumor of unknown malignant potential (STUMP) and stromal sarcoma. Patients and Methods: A 39-year-old patient presented with lower urinary tract symptoms over the last few months. On digital rectal examination, the right lobe of the prostate was diffusely hard on palpation. Prostate-specific antigen was 0.5 ng/ml. A biopsy specimen was obtained with the guidance of transrectal ultrasonography. Immunohistochemical examination revealed positive staining for vimentin, actin, and desmin. Results: 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography scans obtained for staging purposes with the diagnosis of primary spindle cell carcinoma of the prostate revealed widespread lung and liver metastases. A doxorubicin-based systemic chemotherapy (CTx) was initiated. Conclusion: Spindle sarcomas of the prostate have quite aggressive nature and they have high potential to metastase. Average life expectancy is <1 year and the prognosis is poor. CTx and radiation therapy can′t yield curative effects due to poor differentiation.http://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=1;spage=115;epage=119;aulast=ÖztürkDiagnosispositron-emission tomography/computed tomographyprostat cancersarcomaspindle cell prostatic sarcomatreatment |
| spellingShingle | Hakan Öztürk Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings Urology Annals Diagnosis positron-emission tomography/computed tomography prostat cancer sarcoma spindle cell prostatic sarcoma treatment |
| title | Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings |
| title_full | Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings |
| title_fullStr | Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings |
| title_full_unstemmed | Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings |
| title_short | Primary spindle cell sarcoma of the prostate and 18 F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings |
| title_sort | primary spindle cell sarcoma of the prostate and 18 f fluorodeoxyglucose positron emission tomography computed tomography findings |
| topic | Diagnosis positron-emission tomography/computed tomography prostat cancer sarcoma spindle cell prostatic sarcoma treatment |
| url | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=1;spage=115;epage=119;aulast=Öztürk |
| work_keys_str_mv | AT hakanozturk primaryspindlecellsarcomaoftheprostateand18ffluorodeoxyglucosepositronemissiontomographycomputedtomographyfindings |