Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.883513/full |
| _version_ | 1817984243629817856 |
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| author | Xianyi Zhang Xianyi Zhang Chan Chen Yuzhong Xu |
| author_facet | Xianyi Zhang Xianyi Zhang Chan Chen Yuzhong Xu |
| author_sort | Xianyi Zhang |
| collection | DOAJ |
| description | Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early and precise screening. Many studies have reported that Long non-coding RNAs (lncRNAs) play a regulatory role in gene expression in the host immune response against Mtb. Dysregulation of lncRNAs expression patterns associated with immunoregulatory pathways arose in mycobacterial infection. Meanwhile, host-induced lncRNAs regulate antibacterial processes such as apoptosis and autophagy to limit bacterial proliferation. In this review, we try to summarize the latest reports on how dysregulated expressed lncRNAs influence host immune response in tuberculosis infection. We also discuss their potential clinical prospects for tuberculosis diagnosis and development as molecular biomarkers. |
| first_indexed | 2024-04-13T23:42:18Z |
| format | Article |
| id | doaj.art-1cb7b151f7a8481ebbdfd33763f6d69f |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T23:42:18Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-1cb7b151f7a8481ebbdfd33763f6d69f2022-12-22T02:24:26ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-05-011310.3389/fmicb.2022.883513883513Long Non-coding RNAs in Tuberculosis: From Immunity to BiomarkersXianyi Zhang0Xianyi Zhang1Chan Chen2Yuzhong Xu3The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe People’s Hospital of Baoan Shenzhen, Southern Medical University, Shenzhen, ChinaThe People’s Hospital of Baoan Shenzhen, Southern Medical University, Shenzhen, ChinaThe People’s Hospital of Baoan Shenzhen, Southern Medical University, Shenzhen, ChinaTuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early and precise screening. Many studies have reported that Long non-coding RNAs (lncRNAs) play a regulatory role in gene expression in the host immune response against Mtb. Dysregulation of lncRNAs expression patterns associated with immunoregulatory pathways arose in mycobacterial infection. Meanwhile, host-induced lncRNAs regulate antibacterial processes such as apoptosis and autophagy to limit bacterial proliferation. In this review, we try to summarize the latest reports on how dysregulated expressed lncRNAs influence host immune response in tuberculosis infection. We also discuss their potential clinical prospects for tuberculosis diagnosis and development as molecular biomarkers.https://www.frontiersin.org/articles/10.3389/fmicb.2022.883513/fulltuberculosislncRNAimmune responsediagnosisbiomarker |
| spellingShingle | Xianyi Zhang Xianyi Zhang Chan Chen Yuzhong Xu Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers Frontiers in Microbiology tuberculosis lncRNA immune response diagnosis biomarker |
| title | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
| title_full | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
| title_fullStr | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
| title_full_unstemmed | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
| title_short | Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers |
| title_sort | long non coding rnas in tuberculosis from immunity to biomarkers |
| topic | tuberculosis lncRNA immune response diagnosis biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.883513/full |
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