Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
Primary myelofibrosis (PMF) is a type of cloned myeloproliferative neoplasm stemming from haematopoietic stem cells, and tends to transform to acute myeloid leukaemia (AML) in approximately 10–20% of cases over a 10-year period. The transformation into AML has a poor prognosis, with a median overall...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-02-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060518820147 |
| _version_ | 1819022127516352512 |
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| author | Yan Lin Rongrong Lin Guangquan Zhou Yue Liu Weimin Dong Yang Cao Xiaobao Xie Weiying Gu |
| author_facet | Yan Lin Rongrong Lin Guangquan Zhou Yue Liu Weimin Dong Yang Cao Xiaobao Xie Weiying Gu |
| author_sort | Yan Lin |
| collection | DOAJ |
| description | Primary myelofibrosis (PMF) is a type of cloned myeloproliferative neoplasm stemming from haematopoietic stem cells, and tends to transform to acute myeloid leukaemia (AML) in approximately 10–20% of cases over a 10-year period. The transformation into AML has a poor prognosis, with a median overall survival of only 2.6 months in patients receiving supportive treatment. To date, treatment of AML transformation remains poor. The case of a 58-year-old female patient with AML transformed from PMF, who was treated with decitabine combined with all-trans retinoic acid, is reported. The patient had complete remission and a 17-month overall survival from initial diagnosis of transformed AML, with tolerated haematologic toxicity during the treatment period. |
| first_indexed | 2024-12-21T04:18:03Z |
| format | Article |
| id | doaj.art-1cb9f1ba92084fbaaf36c2753e37f350 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T04:18:03Z |
| publishDate | 2019-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-1cb9f1ba92084fbaaf36c2753e37f3502022-12-21T19:16:15ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002019-02-014710.1177/0300060518820147Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemiaYan LinRongrong LinGuangquan ZhouYue LiuWeimin DongYang CaoXiaobao XieWeiying GuPrimary myelofibrosis (PMF) is a type of cloned myeloproliferative neoplasm stemming from haematopoietic stem cells, and tends to transform to acute myeloid leukaemia (AML) in approximately 10–20% of cases over a 10-year period. The transformation into AML has a poor prognosis, with a median overall survival of only 2.6 months in patients receiving supportive treatment. To date, treatment of AML transformation remains poor. The case of a 58-year-old female patient with AML transformed from PMF, who was treated with decitabine combined with all-trans retinoic acid, is reported. The patient had complete remission and a 17-month overall survival from initial diagnosis of transformed AML, with tolerated haematologic toxicity during the treatment period.https://doi.org/10.1177/0300060518820147 |
| spellingShingle | Yan Lin Rongrong Lin Guangquan Zhou Yue Liu Weimin Dong Yang Cao Xiaobao Xie Weiying Gu Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia Journal of International Medical Research |
| title | Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia |
| title_full | Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia |
| title_fullStr | Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia |
| title_full_unstemmed | Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia |
| title_short | Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia |
| title_sort | decitabine combined with all trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia |
| url | https://doi.org/10.1177/0300060518820147 |
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