Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study
Abstract Background Growing evidence indicates that in utero arsenic exposures in humans may increase the risk of adverse health effects and development of diseases later in life. This study aimed to evaluate potential health risks of in utero arsenic exposure on genetic damage in newborns in relati...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Environmental Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12940-019-0481-7 |
| _version_ | 1818974475619663872 |
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| author | Panida Navasumrit Krittinee Chaisatra Jeerawan Promvijit Varabhorn Parnlob Somchamai Waraprasit Chalida Chompoobut Ta Thi Binh Doan Ngoc Hai Nguyen Duy Bao Nguyen Khac Hai Kyoung-Woong Kim Leona D. Samson Joseph H. Graziano Chulabhorn Mahidol Mathuros Ruchirawat |
| author_facet | Panida Navasumrit Krittinee Chaisatra Jeerawan Promvijit Varabhorn Parnlob Somchamai Waraprasit Chalida Chompoobut Ta Thi Binh Doan Ngoc Hai Nguyen Duy Bao Nguyen Khac Hai Kyoung-Woong Kim Leona D. Samson Joseph H. Graziano Chulabhorn Mahidol Mathuros Ruchirawat |
| author_sort | Panida Navasumrit |
| collection | DOAJ |
| description | Abstract Background Growing evidence indicates that in utero arsenic exposures in humans may increase the risk of adverse health effects and development of diseases later in life. This study aimed to evaluate potential health risks of in utero arsenic exposure on genetic damage in newborns in relation to maternal arsenic exposure. Methods A total of 205 pregnant women residing in arsenic-contaminated areas in Hanam province, Vietnam, were recruited. Prenatal arsenic exposure was determined by arsenic concentration in mother’s toenails and urine during pregnancy and in umbilical cord blood collected at delivery. Genetic damage in newborns was assessed by various biomarkers of early genetic effects including oxidative/nitrative DNA damage (8-hydroxydeoxyguanosine, 8-OHdG, and 8-nitroguanine), DNA strand breaks and micronuclei (MN) in cord blood. Results Maternal arsenic exposure, measured by arsenic levels in toenails and urine, was significantly increased (p < 0.05) in subjects residing in areas with high levels of arsenic contamination in drinking water. Cord blood arsenic level was significantly increased in accordance with maternal arsenic exposure (p < 0.001). Arsenic exposure in utero is associated with genotoxic effects in newborns indicated as increased levels of 8-OHdG, 8-nitroguanine, DNA strand breaks and MN frequency in cord blood with increasing levels of maternal arsenic exposure. Maternal toenail arsenic level was significantly associated with all biomarkers of early genetic effects, while cord blood arsenic levels associated with DNA strand breaks and MN frequency. Conclusions In utero arsenic exposure is associated with various types of genetic damage in newborns potentially contributing to the development of diseases, including cancer, later in life. |
| first_indexed | 2024-12-20T15:40:39Z |
| format | Article |
| id | doaj.art-1cbc9fbcfe4b4ad1b3d33e25b9be23d3 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-20T15:40:39Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-1cbc9fbcfe4b4ad1b3d33e25b9be23d32022-12-21T19:35:12ZengBMCEnvironmental Health1476-069X2019-06-0118111610.1186/s12940-019-0481-7Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort studyPanida Navasumrit0Krittinee Chaisatra1Jeerawan Promvijit2Varabhorn Parnlob3Somchamai Waraprasit4Chalida Chompoobut5Ta Thi Binh6Doan Ngoc Hai7Nguyen Duy Bao8Nguyen Khac Hai9Kyoung-Woong Kim10Leona D. Samson11Joseph H. Graziano12Chulabhorn Mahidol13Mathuros Ruchirawat14Laboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteNational Institute of Occupational and Environmental HealthNational Institute of Occupational and Environmental HealthNational Institute of Occupational and Environmental HealthNational Institute of Occupational and Environmental HealthInternational Environmental Research Center, Gwangju Institute of Science and TechnologyCenter for Environmental Health Sciences, Massachusetts Institute of TechnologyDepartment of Environmental Health Sciences, Columbia UniversityLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteLaboratories of Environmental Toxicology/Chemical Carcinogenesis, Chulabhorn Research InstituteAbstract Background Growing evidence indicates that in utero arsenic exposures in humans may increase the risk of adverse health effects and development of diseases later in life. This study aimed to evaluate potential health risks of in utero arsenic exposure on genetic damage in newborns in relation to maternal arsenic exposure. Methods A total of 205 pregnant women residing in arsenic-contaminated areas in Hanam province, Vietnam, were recruited. Prenatal arsenic exposure was determined by arsenic concentration in mother’s toenails and urine during pregnancy and in umbilical cord blood collected at delivery. Genetic damage in newborns was assessed by various biomarkers of early genetic effects including oxidative/nitrative DNA damage (8-hydroxydeoxyguanosine, 8-OHdG, and 8-nitroguanine), DNA strand breaks and micronuclei (MN) in cord blood. Results Maternal arsenic exposure, measured by arsenic levels in toenails and urine, was significantly increased (p < 0.05) in subjects residing in areas with high levels of arsenic contamination in drinking water. Cord blood arsenic level was significantly increased in accordance with maternal arsenic exposure (p < 0.001). Arsenic exposure in utero is associated with genotoxic effects in newborns indicated as increased levels of 8-OHdG, 8-nitroguanine, DNA strand breaks and MN frequency in cord blood with increasing levels of maternal arsenic exposure. Maternal toenail arsenic level was significantly associated with all biomarkers of early genetic effects, while cord blood arsenic levels associated with DNA strand breaks and MN frequency. Conclusions In utero arsenic exposure is associated with various types of genetic damage in newborns potentially contributing to the development of diseases, including cancer, later in life.http://link.springer.com/article/10.1186/s12940-019-0481-7ArsenicMaternal exposureIn utero exposureGenetic damage8-nitroguanine8- hydroxydeoxyguanosine, DNA strand breaks, Micronucleus |
| spellingShingle | Panida Navasumrit Krittinee Chaisatra Jeerawan Promvijit Varabhorn Parnlob Somchamai Waraprasit Chalida Chompoobut Ta Thi Binh Doan Ngoc Hai Nguyen Duy Bao Nguyen Khac Hai Kyoung-Woong Kim Leona D. Samson Joseph H. Graziano Chulabhorn Mahidol Mathuros Ruchirawat Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study Environmental Health Arsenic Maternal exposure In utero exposure Genetic damage 8-nitroguanine 8- hydroxydeoxyguanosine, DNA strand breaks, Micronucleus |
| title | Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study |
| title_full | Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study |
| title_fullStr | Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study |
| title_full_unstemmed | Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study |
| title_short | Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study |
| title_sort | exposure to arsenic in utero is associated with various types of dna damage and micronuclei in newborns a birth cohort study |
| topic | Arsenic Maternal exposure In utero exposure Genetic damage 8-nitroguanine 8- hydroxydeoxyguanosine, DNA strand breaks, Micronucleus |
| url | http://link.springer.com/article/10.1186/s12940-019-0481-7 |
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