Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical appli...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1292149/full |
| _version_ | 1797643309198344192 |
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| author | Meiping Zhao Meili Huang Zhen Li |
| author_facet | Meiping Zhao Meili Huang Zhen Li |
| author_sort | Meiping Zhao |
| collection | DOAJ |
| description | Lysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical application has yet to be realized. Current research is primarily focused on carrier-based delivery systems for lysozyme. In this review, we discuss four delivery systems that can be employed for lysozyme in wound healing treatment, specifically hydrogels, nanofilms, electrospun fibrous membranes, and modified-lysozyme composite systems. These systems not only enhance the stability of lysozyme but also enable its controlled and sustained release at wound sites, potentially overcoming some of the challenges associated with its direct application. Lastly, we delve into the perspectives and challenges related to the use of these delivery systems, hoping to spur further research and innovation in this promising field. |
| first_indexed | 2024-03-11T14:12:57Z |
| format | Article |
| id | doaj.art-1cbe35fbaf874cbbb44b8aa3a43cedb9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-11T14:12:57Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-1cbe35fbaf874cbbb44b8aa3a43cedb92023-11-01T16:17:07ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-11-011110.3389/fbioe.2023.12921491292149Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterialMeiping Zhao0Meili Huang1Zhen Li2Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaNursing Department, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine Alar Hospital, Alar, ChinaEmergency Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaLysozyme, a natural antibacterial enzyme protein, possesses the ability to dissolve the cell walls of Gram-positive bacteria, demonstrating broad-spectrum antibacterial activity. Despite its significant potential in treating wound infections and promoting wound healing, its widespread clinical application has yet to be realized. Current research is primarily focused on carrier-based delivery systems for lysozyme. In this review, we discuss four delivery systems that can be employed for lysozyme in wound healing treatment, specifically hydrogels, nanofilms, electrospun fibrous membranes, and modified-lysozyme composite systems. These systems not only enhance the stability of lysozyme but also enable its controlled and sustained release at wound sites, potentially overcoming some of the challenges associated with its direct application. Lastly, we delve into the perspectives and challenges related to the use of these delivery systems, hoping to spur further research and innovation in this promising field.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1292149/fulllysozymewound healingantibacterialwound dressinghydrogels |
| spellingShingle | Meiping Zhao Meili Huang Zhen Li Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial Frontiers in Bioengineering and Biotechnology lysozyme wound healing antibacterial wound dressing hydrogels |
| title | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
| title_full | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
| title_fullStr | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
| title_full_unstemmed | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
| title_short | Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial |
| title_sort | exploring the therapeutic potential of recombinant human lysozyme a review on wound management system with antibacterial |
| topic | lysozyme wound healing antibacterial wound dressing hydrogels |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1292149/full |
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