Role of Energy Metabolism in the Progression of Neuroblastoma
Neuroblastoma is a common childhood cancer possessing a significant risk of death. This solid tumor manifests variable clinical behaviors ranging from spontaneous regression to widespread metastatic disease. The lack of promising treatments calls for new research approaches which can enhance the und...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11421 |
| _version_ | 1797512477336928256 |
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| author | Monika Sakowicz-Burkiewicz Tadeusz Pawełczyk Marlena Zyśk |
| author_facet | Monika Sakowicz-Burkiewicz Tadeusz Pawełczyk Marlena Zyśk |
| author_sort | Monika Sakowicz-Burkiewicz |
| collection | DOAJ |
| description | Neuroblastoma is a common childhood cancer possessing a significant risk of death. This solid tumor manifests variable clinical behaviors ranging from spontaneous regression to widespread metastatic disease. The lack of promising treatments calls for new research approaches which can enhance the understanding of the molecular background of neuroblastoma. The high proliferation of malignant neuroblastoma cells requires efficient energy metabolism. Thus, we focus our attention on energy pathways and their role in neuroblastoma tumorigenesis. Recent studies suggest that neuroblastoma-driven extracellular vesicles stimulate tumorigenesis inside the recipient cells. Furthermore, proteomic studies have demonstrated extracellular vesicles (EVs) to cargo metabolic enzymes needed to build up a fully operative energy metabolism network. The majority of EV-derived enzymes comes from glycolysis, while other metabolic enzymes have a fatty acid β-oxidation and tricarboxylic acid cycle origin. The previously mentioned glycolysis has been shown to play a primary role in neuroblastoma energy metabolism. Therefore, another way to modify the energy metabolism in neuroblastoma is linked with genetic alterations resulting in the decreased activity of some tricarboxylic acid cycle enzymes and enhanced glycolysis. This metabolic shift enables malignant cells to cope with increasing metabolic stress, nutrition breakdown and an upregulated proliferation ratio. |
| first_indexed | 2024-03-10T06:02:23Z |
| format | Article |
| id | doaj.art-1cbec4635d8c4a50ba8b66b16b06fb15 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:02:23Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1cbec4635d8c4a50ba8b66b16b06fb152023-11-22T20:51:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211142110.3390/ijms222111421Role of Energy Metabolism in the Progression of NeuroblastomaMonika Sakowicz-Burkiewicz0Tadeusz Pawełczyk1Marlena Zyśk2Department of Molecular Medicine, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Molecular Medicine, Medical University of Gdansk, 80-211 Gdansk, PolandDepartment of Molecular Medicine, Medical University of Gdansk, 80-211 Gdansk, PolandNeuroblastoma is a common childhood cancer possessing a significant risk of death. This solid tumor manifests variable clinical behaviors ranging from spontaneous regression to widespread metastatic disease. The lack of promising treatments calls for new research approaches which can enhance the understanding of the molecular background of neuroblastoma. The high proliferation of malignant neuroblastoma cells requires efficient energy metabolism. Thus, we focus our attention on energy pathways and their role in neuroblastoma tumorigenesis. Recent studies suggest that neuroblastoma-driven extracellular vesicles stimulate tumorigenesis inside the recipient cells. Furthermore, proteomic studies have demonstrated extracellular vesicles (EVs) to cargo metabolic enzymes needed to build up a fully operative energy metabolism network. The majority of EV-derived enzymes comes from glycolysis, while other metabolic enzymes have a fatty acid β-oxidation and tricarboxylic acid cycle origin. The previously mentioned glycolysis has been shown to play a primary role in neuroblastoma energy metabolism. Therefore, another way to modify the energy metabolism in neuroblastoma is linked with genetic alterations resulting in the decreased activity of some tricarboxylic acid cycle enzymes and enhanced glycolysis. This metabolic shift enables malignant cells to cope with increasing metabolic stress, nutrition breakdown and an upregulated proliferation ratio.https://www.mdpi.com/1422-0067/22/21/11421neuroblastomaglycolysisextracellular vesicles |
| spellingShingle | Monika Sakowicz-Burkiewicz Tadeusz Pawełczyk Marlena Zyśk Role of Energy Metabolism in the Progression of Neuroblastoma International Journal of Molecular Sciences neuroblastoma glycolysis extracellular vesicles |
| title | Role of Energy Metabolism in the Progression of Neuroblastoma |
| title_full | Role of Energy Metabolism in the Progression of Neuroblastoma |
| title_fullStr | Role of Energy Metabolism in the Progression of Neuroblastoma |
| title_full_unstemmed | Role of Energy Metabolism in the Progression of Neuroblastoma |
| title_short | Role of Energy Metabolism in the Progression of Neuroblastoma |
| title_sort | role of energy metabolism in the progression of neuroblastoma |
| topic | neuroblastoma glycolysis extracellular vesicles |
| url | https://www.mdpi.com/1422-0067/22/21/11421 |
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