| Summary: | The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of
an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is
reported for potential administration through transdermal route. The investigation was carried out to
study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic
polymer respectively. Transdermal patches were prepared using different combination of the two
polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing
membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture
content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all
the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with
highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl
cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a
period of 24 hrs.
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