A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties
In recent years, there has been increasing interest in dimeric molecules due to reports of their promising therapeutic value in the treatment of numerous diseases (such as cancer, HIV, Alzheimer’s and, malaria). Many reports in the literature have highlighted the ability of these molecules...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/24/1/108 |
| _version_ | 1818880368224239616 |
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| author | Valeria Romanucci Giovanni Di Fabio Armando Zarrelli |
| author_facet | Valeria Romanucci Giovanni Di Fabio Armando Zarrelli |
| author_sort | Valeria Romanucci |
| collection | DOAJ |
| description | In recent years, there has been increasing interest in dimeric molecules due to reports of their promising therapeutic value in the treatment of numerous diseases (such as cancer, HIV, Alzheimer’s and, malaria). Many reports in the literature have highlighted the ability of these molecules to interact not only with specific biologic receptors but also to induce a biological response that more than doubles the results of the corresponding monomeric counterpart. In this regard, flavonolignan dimers or simply bi-flavonolignans are an emerging class of dimeric compounds that unlike bi-flavonoids, which are very widespread in nature, consist of synthetic dimers of some flavonolignans isolated from the milk thistle Silybum marianum [L. Gaertn. (Asteraceae)]. This mini-review will discuss recent developments in the synthesis, characterization and antioxidant activity of new families of flavonolignan dimers, in light of emerging medicinal chemistry strategies. |
| first_indexed | 2024-12-19T14:44:51Z |
| format | Article |
| id | doaj.art-1cc0e153a50f45aca731fd61db4a2438 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T14:44:51Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1cc0e153a50f45aca731fd61db4a24382022-12-21T20:16:59ZengMDPI AGMolecules1420-30492018-12-0124110810.3390/molecules24010108molecules24010108A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive PropertiesValeria Romanucci0Giovanni Di Fabio1Armando Zarrelli2Department of Chemical Sciences, University of Napoli ‘Federico II’, Via Cintia 4, I-80126 Napoli, ItalyDepartment of Chemical Sciences, University of Napoli ‘Federico II’, Via Cintia 4, I-80126 Napoli, ItalyDepartment of Chemical Sciences, University of Napoli ‘Federico II’, Via Cintia 4, I-80126 Napoli, ItalyIn recent years, there has been increasing interest in dimeric molecules due to reports of their promising therapeutic value in the treatment of numerous diseases (such as cancer, HIV, Alzheimer’s and, malaria). Many reports in the literature have highlighted the ability of these molecules to interact not only with specific biologic receptors but also to induce a biological response that more than doubles the results of the corresponding monomeric counterpart. In this regard, flavonolignan dimers or simply bi-flavonolignans are an emerging class of dimeric compounds that unlike bi-flavonoids, which are very widespread in nature, consist of synthetic dimers of some flavonolignans isolated from the milk thistle Silybum marianum [L. Gaertn. (Asteraceae)]. This mini-review will discuss recent developments in the synthesis, characterization and antioxidant activity of new families of flavonolignan dimers, in light of emerging medicinal chemistry strategies.http://www.mdpi.com/1420-3049/24/1/108flavonolignansmilk thistleSilybum marianumsilymarinsilibininsilybin |
| spellingShingle | Valeria Romanucci Giovanni Di Fabio Armando Zarrelli A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties Molecules flavonolignans milk thistle Silybum marianum silymarin silibinin silybin |
| title | A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties |
| title_full | A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties |
| title_fullStr | A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties |
| title_full_unstemmed | A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties |
| title_short | A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties |
| title_sort | new class of synthetic flavonolignan like dimers still few molecules but with attractive properties |
| topic | flavonolignans milk thistle Silybum marianum silymarin silibinin silybin |
| url | http://www.mdpi.com/1420-3049/24/1/108 |
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