Algal Lipids as Modulators of Skin Disease: A Critical Review
The prevalence of inflammatory skin diseases continues to increase with a high incidence in children and adults. These diseases are triggered by environmental factors, such as UV radiation, certain chemical compounds, infectious agents, and in some cases, people with a genetic predisposition. The pa...
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MDPI AG
2022-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/2/96 |
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| author | Tiago Conde Diana Lopes Wojciech Łuczaj Bruno Neves Bruno Pinto Tatiana Maurício Pedro Domingues Elżbieta Skrzydlewska M. Rosário Domingues |
| author_facet | Tiago Conde Diana Lopes Wojciech Łuczaj Bruno Neves Bruno Pinto Tatiana Maurício Pedro Domingues Elżbieta Skrzydlewska M. Rosário Domingues |
| author_sort | Tiago Conde |
| collection | DOAJ |
| description | The prevalence of inflammatory skin diseases continues to increase with a high incidence in children and adults. These diseases are triggered by environmental factors, such as UV radiation, certain chemical compounds, infectious agents, and in some cases, people with a genetic predisposition. The pathophysiology of inflammatory skin diseases such as psoriasis or atopic dermatitis, but also of skin cancers, is the result of the activation of inflammation-related metabolic pathways and the overproduction of pro-inflammatory cytokines observed in in vitro and in vivo studies. Inflammatory skin diseases are also associated with oxidative stress, overproduction of ROS, and impaired antioxidant defense, which affects the metabolism of immune cells and skin cells (keratinocytes and fibroblasts) in systemic and skin disorders. Lipids from algae have been scarcely applied to modulate skin diseases, but they are well known antioxidant and anti-inflammatory agents. They have shown scavenging activities and can modulate redox homeostasis enzymes. They can also downmodulate key inflammatory signaling pathways and transcription factors such as NF-κB, decreasing the expression of pro-inflammatory mediators. Thus, the exploitation of algae lipids as therapeutical agents for the treatment of inflammatory skin diseases is highly attractive, being critically reviewed in the present work. |
| first_indexed | 2024-03-09T21:27:14Z |
| format | Article |
| id | doaj.art-1cc15708f1d240f7b2ea019e9c9bce23 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T21:27:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-1cc15708f1d240f7b2ea019e9c9bce232023-11-23T21:04:21ZengMDPI AGMetabolites2218-19892022-01-011229610.3390/metabo12020096Algal Lipids as Modulators of Skin Disease: A Critical ReviewTiago Conde0Diana Lopes1Wojciech Łuczaj2Bruno Neves3Bruno Pinto4Tatiana Maurício5Pedro Domingues6Elżbieta Skrzydlewska7M. Rosário Domingues8Centre for Environmental and Marine Studies, CESAM, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalCentre for Environmental and Marine Studies, CESAM, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandDepartment of Medical Sciences, Institute of Biomedicine–iBiMED, University of Aveiro, 3810-193 Aveiro, PortugalCentre for Environmental and Marine Studies, CESAM, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalMass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalMass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandCentre for Environmental and Marine Studies, CESAM, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, PortugalThe prevalence of inflammatory skin diseases continues to increase with a high incidence in children and adults. These diseases are triggered by environmental factors, such as UV radiation, certain chemical compounds, infectious agents, and in some cases, people with a genetic predisposition. The pathophysiology of inflammatory skin diseases such as psoriasis or atopic dermatitis, but also of skin cancers, is the result of the activation of inflammation-related metabolic pathways and the overproduction of pro-inflammatory cytokines observed in in vitro and in vivo studies. Inflammatory skin diseases are also associated with oxidative stress, overproduction of ROS, and impaired antioxidant defense, which affects the metabolism of immune cells and skin cells (keratinocytes and fibroblasts) in systemic and skin disorders. Lipids from algae have been scarcely applied to modulate skin diseases, but they are well known antioxidant and anti-inflammatory agents. They have shown scavenging activities and can modulate redox homeostasis enzymes. They can also downmodulate key inflammatory signaling pathways and transcription factors such as NF-κB, decreasing the expression of pro-inflammatory mediators. Thus, the exploitation of algae lipids as therapeutical agents for the treatment of inflammatory skin diseases is highly attractive, being critically reviewed in the present work.https://www.mdpi.com/2218-1989/12/2/96skin diseasesinflammationoxidative stresslipidomicsbioactive lipidsanti-inflammatory |
| spellingShingle | Tiago Conde Diana Lopes Wojciech Łuczaj Bruno Neves Bruno Pinto Tatiana Maurício Pedro Domingues Elżbieta Skrzydlewska M. Rosário Domingues Algal Lipids as Modulators of Skin Disease: A Critical Review Metabolites skin diseases inflammation oxidative stress lipidomics bioactive lipids anti-inflammatory |
| title | Algal Lipids as Modulators of Skin Disease: A Critical Review |
| title_full | Algal Lipids as Modulators of Skin Disease: A Critical Review |
| title_fullStr | Algal Lipids as Modulators of Skin Disease: A Critical Review |
| title_full_unstemmed | Algal Lipids as Modulators of Skin Disease: A Critical Review |
| title_short | Algal Lipids as Modulators of Skin Disease: A Critical Review |
| title_sort | algal lipids as modulators of skin disease a critical review |
| topic | skin diseases inflammation oxidative stress lipidomics bioactive lipids anti-inflammatory |
| url | https://www.mdpi.com/2218-1989/12/2/96 |
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