Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease
The beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs...
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1479 |
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| author | Martin Wawruch Jan Murin Tomas Tesar Martina Paduchova Miriam Petrova Denisa Celovska Beata Havelkova Michal Trnka Lucia Masarykova Sofa D. Alfian Emma Aarnio |
| author_facet | Martin Wawruch Jan Murin Tomas Tesar Martina Paduchova Miriam Petrova Denisa Celovska Beata Havelkova Michal Trnka Lucia Masarykova Sofa D. Alfian Emma Aarnio |
| author_sort | Martin Wawruch |
| collection | DOAJ |
| description | The beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs/ARBs, and to identify the characteristics associated with the likelihood of non-persistence. Our study cohort included 7080 hypertensive patients (4005 women and 3075 men) aged ≥65 years, treated with ACEIs/ARBs, in whom PAD was diagnosed between 1 January and 31 December 2012. Non-persistence was identified according to a treatment gap of 6 months without ACEI/ARB prescriptions. The characteristics associated with non-persistence were identified using the Cox regression model. At the end of the 5-year follow-up, 23.2% of the whole study cohort, 22.3% of men, and 23.9% of women were non-persistent with ACEIs/ARBs, with no significant gender differences in persistence. While a number of characteristics were associated with non-persistence, only three characteristics had consistent, statistically significant associations in both genders: being a new ACEI/ARB user increased the likelihood of non-persistence, and general practitioner as index prescriber and increasing the overall number of medications decreased the likelihood of non-persistence. Information on the differences in characteristics that are associated with non-persistence between genders may help to better identify patients for whom special attention should be paid to improve their persistence. |
| first_indexed | 2024-03-09T12:12:26Z |
| format | Article |
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| language | English |
| last_indexed | 2024-03-09T12:12:26Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1cc2ce2ae51840eebbe8ab3335db41642023-11-30T22:49:46ZengMDPI AGBiomedicines2227-90592022-06-01107147910.3390/biomedicines10071479Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial DiseaseMartin Wawruch0Jan Murin1Tomas Tesar2Martina Paduchova3Miriam Petrova4Denisa Celovska5Beata Havelkova6Michal Trnka7Lucia Masarykova8Sofa D. Alfian9Emma Aarnio10Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia1st Department of Internal Medicine, Faculty of Medicine, Comenius University, 813 69 Bratislava, SlovakiaDepartment of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, SlovakiaDepartment of Angiology, Health Centre, 917 01 Trnava, SlovakiaInstitute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia1st Department of Internal Medicine, Faculty of Medicine, Comenius University, 813 69 Bratislava, SlovakiaGeneral Health Insurance Company, 851 04 Bratislava, SlovakiaInstitute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, 813 72 Bratislava, SlovakiaDepartment of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, SlovakiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaSchool of Pharmacy, University of Eastern Finland, 70211 Kuopio, FinlandThe beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs/ARBs, and to identify the characteristics associated with the likelihood of non-persistence. Our study cohort included 7080 hypertensive patients (4005 women and 3075 men) aged ≥65 years, treated with ACEIs/ARBs, in whom PAD was diagnosed between 1 January and 31 December 2012. Non-persistence was identified according to a treatment gap of 6 months without ACEI/ARB prescriptions. The characteristics associated with non-persistence were identified using the Cox regression model. At the end of the 5-year follow-up, 23.2% of the whole study cohort, 22.3% of men, and 23.9% of women were non-persistent with ACEIs/ARBs, with no significant gender differences in persistence. While a number of characteristics were associated with non-persistence, only three characteristics had consistent, statistically significant associations in both genders: being a new ACEI/ARB user increased the likelihood of non-persistence, and general practitioner as index prescriber and increasing the overall number of medications decreased the likelihood of non-persistence. Information on the differences in characteristics that are associated with non-persistence between genders may help to better identify patients for whom special attention should be paid to improve their persistence.https://www.mdpi.com/2227-9059/10/7/1479peripheral arterial diseaseadherencepersistenceangiotensin-converting enzyme inhibitorsangiotensin receptor blockersgeneral practitioner |
| spellingShingle | Martin Wawruch Jan Murin Tomas Tesar Martina Paduchova Miriam Petrova Denisa Celovska Beata Havelkova Michal Trnka Lucia Masarykova Sofa D. Alfian Emma Aarnio Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease Biomedicines peripheral arterial disease adherence persistence angiotensin-converting enzyme inhibitors angiotensin receptor blockers general practitioner |
| title | Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease |
| title_full | Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease |
| title_fullStr | Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease |
| title_full_unstemmed | Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease |
| title_short | Gender Differences in Non-Persistence with Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers among Older Hypertensive Patients with Peripheral Arterial Disease |
| title_sort | gender differences in non persistence with angiotensin converting enzyme inhibitors and angiotensin receptor blockers among older hypertensive patients with peripheral arterial disease |
| topic | peripheral arterial disease adherence persistence angiotensin-converting enzyme inhibitors angiotensin receptor blockers general practitioner |
| url | https://www.mdpi.com/2227-9059/10/7/1479 |
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