Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device
Results of topical treatments can be influenced by several factors, including accurate dosing based on the affected skin area. The aim of this open-labelled multicenter study is to evaluate if correct dosing of calcitriol ointment has an impact on the clinical response of plaque psoriasis. For this...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2007-05-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X0700500205 |
| _version_ | 1818528894689476608 |
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| author | G.A. Vena N. Cassano G. Alessandrini D. Fai M. Gabellone P. Ligori C. Malvindi A. Mancino S. Pellè F. Rinaldi M.R. Sodo |
| author_facet | G.A. Vena N. Cassano G. Alessandrini D. Fai M. Gabellone P. Ligori C. Malvindi A. Mancino S. Pellè F. Rinaldi M.R. Sodo |
| author_sort | G.A. Vena |
| collection | DOAJ |
| description | Results of topical treatments can be influenced by several factors, including accurate dosing based on the affected skin area. The aim of this open-labelled multicenter study is to evaluate if correct dosing of calcitriol ointment has an impact on the clinical response of plaque psoriasis. For this purpose, patients with plaque psoriasis eligible to be treated with calcitriol ointment were randomized to treatment with a ‘standardized dose’ method, using a dosing device (N. 100), or treatment without the device (N. 101), for 12 weeks. Regardless of the use of the dosing device, calcitriol ointment caused a significant reduction of both the severity of signs and symptoms and the extent of body surface area affected after both 4 weeks and 12 weeks. Clinical response was not significantly different between the two groups. Local adverse events occurred in 12 subjects (of whom five treated with the device) and were mild and transient in most cases. |
| first_indexed | 2024-12-11T06:55:59Z |
| format | Article |
| id | doaj.art-1cc3a30fad764b2cab47487cfd64660c |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-11T06:55:59Z |
| publishDate | 2007-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-1cc3a30fad764b2cab47487cfd64660c2022-12-22T01:16:45ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2007-05-01510.1177/1721727X0700500205Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing DeviceG.A. VenaN. CassanoG. Alessandrini0D. Fai1M. Gabellone2P. Ligori3C. Malvindi4A. Mancino5S. Pellè6F. Rinaldi7M.R. Sodo8 Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, Italy Collegio Salentino di Dermatologia, Lecce, ItalyResults of topical treatments can be influenced by several factors, including accurate dosing based on the affected skin area. The aim of this open-labelled multicenter study is to evaluate if correct dosing of calcitriol ointment has an impact on the clinical response of plaque psoriasis. For this purpose, patients with plaque psoriasis eligible to be treated with calcitriol ointment were randomized to treatment with a ‘standardized dose’ method, using a dosing device (N. 100), or treatment without the device (N. 101), for 12 weeks. Regardless of the use of the dosing device, calcitriol ointment caused a significant reduction of both the severity of signs and symptoms and the extent of body surface area affected after both 4 weeks and 12 weeks. Clinical response was not significantly different between the two groups. Local adverse events occurred in 12 subjects (of whom five treated with the device) and were mild and transient in most cases.https://doi.org/10.1177/1721727X0700500205 |
| spellingShingle | G.A. Vena N. Cassano G. Alessandrini D. Fai M. Gabellone P. Ligori C. Malvindi A. Mancino S. Pellè F. Rinaldi M.R. Sodo Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device European Journal of Inflammation |
| title | Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device |
| title_full | Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device |
| title_fullStr | Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device |
| title_full_unstemmed | Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device |
| title_short | Treatment of Mild to Moderate Plaque Psoriasis with Calcitriol Ointment Applied with or without a Dosing Device |
| title_sort | treatment of mild to moderate plaque psoriasis with calcitriol ointment applied with or without a dosing device |
| url | https://doi.org/10.1177/1721727X0700500205 |
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