Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy
Ravi K Goyal,1 Jingchuan Zhang,2 Keith L Davis,1 Martina Sluga-O’Callaghan,1 Peter A Kaufman3 1Health Economics, RTI Health Solutions, Research Triangle Park, NC, USA; 2Eisai Inc., Nutley, NJ, USA; 3Larner College of Medicine, Division of Hematology/Oncology, University of Vermont Cancer Center, Bur...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/early-real-world-treatment-patterns-and-clinical-outcomes-in-patients--peer-reviewed-fulltext-article-BCTT |
| _version_ | 1797572310023012352 |
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| author | Goyal RK Zhang J Davis KL Sluga-O'Callaghan M Kaufman PA |
| author_facet | Goyal RK Zhang J Davis KL Sluga-O'Callaghan M Kaufman PA |
| author_sort | Goyal RK |
| collection | DOAJ |
| description | Ravi K Goyal,1 Jingchuan Zhang,2 Keith L Davis,1 Martina Sluga-O’Callaghan,1 Peter A Kaufman3 1Health Economics, RTI Health Solutions, Research Triangle Park, NC, USA; 2Eisai Inc., Nutley, NJ, USA; 3Larner College of Medicine, Division of Hematology/Oncology, University of Vermont Cancer Center, Burlington, VT, USACorrespondence: Peter A Kaufman, Larner College of Medicine, Division of Hematology/Oncology, University of Vermont Cancer Center, 111 Colchester Avenue, EP2, Burlington, VT, 05401, USA, Email Peter.Kaufman@uvmhealth.orgIntroduction: Eribulin was approved by the FDA in 2010 for the treatment of metastatic breast cancer (MBC) in the United States (US). More recently, several immuno-oncology (IO) and antibody–drug conjugate (ADC) regimens have been approved for MBC. We assessed the treatment patterns and clinical outcomes in MBC patients treated with eribulin following treatment with an IO or ADC in US clinical practice.Materials and Methods: In a retrospective patient medical chart review study, patients with MBC, aged ≥ 18 years, who initiated eribulin therapy between March 1, 2019, and September 30, 2020, treated with either prior IO or ADC in the metastatic setting were included. Patient demographics, treatment characteristics, and clinical outcomes were analyzed descriptively. Real-world progression-free survival (rwPFS) and overall survival (OS) were estimated using Kaplan–Meier analyses.Results: In the study population (N=143), median age at eribulin initiation was 62 years; 64% were Caucasian, and 67% had triple-negative MBC (TNBC). Eribulin therapy was used in the second to fifth line of therapy in the metastatic setting; median treatment duration was 7.2 months. The overall response rate for eribulin was 59.4%. Median rwPFS and OS from eribulin initiation were 21.4 months (95% CI, 12.9-not estimable [NE]) and 24.2 months (95% CI, 17.5-NE), respectively. In patients with TNBC, median rwPFS and OS from eribulin initiation were 12.0 months (95% CI, 8.8-NE) and 18.3 months (95% CI, 14.9-NE), respectively.Conclusion: These real-world data provide evidence for the clinical effectiveness outcomes of eribulin treatment among MBC patients previously treated with an IO or ADC.Keywords: real world evidence, metastatic breast cancer, immuno-oncology, antibody drug conjugates, eribulin, patient medical chart review |
| first_indexed | 2024-03-10T20:54:26Z |
| format | Article |
| id | doaj.art-1cc6e3edfdd04da59c9ffab0c1e0dce4 |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-03-10T20:54:26Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-1cc6e3edfdd04da59c9ffab0c1e0dce42023-11-19T18:03:58ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142023-11-01Volume 1585586588276Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate TherapyGoyal RKZhang JDavis KLSluga-O'Callaghan MKaufman PARavi K Goyal,1 Jingchuan Zhang,2 Keith L Davis,1 Martina Sluga-O’Callaghan,1 Peter A Kaufman3 1Health Economics, RTI Health Solutions, Research Triangle Park, NC, USA; 2Eisai Inc., Nutley, NJ, USA; 3Larner College of Medicine, Division of Hematology/Oncology, University of Vermont Cancer Center, Burlington, VT, USACorrespondence: Peter A Kaufman, Larner College of Medicine, Division of Hematology/Oncology, University of Vermont Cancer Center, 111 Colchester Avenue, EP2, Burlington, VT, 05401, USA, Email Peter.Kaufman@uvmhealth.orgIntroduction: Eribulin was approved by the FDA in 2010 for the treatment of metastatic breast cancer (MBC) in the United States (US). More recently, several immuno-oncology (IO) and antibody–drug conjugate (ADC) regimens have been approved for MBC. We assessed the treatment patterns and clinical outcomes in MBC patients treated with eribulin following treatment with an IO or ADC in US clinical practice.Materials and Methods: In a retrospective patient medical chart review study, patients with MBC, aged ≥ 18 years, who initiated eribulin therapy between March 1, 2019, and September 30, 2020, treated with either prior IO or ADC in the metastatic setting were included. Patient demographics, treatment characteristics, and clinical outcomes were analyzed descriptively. Real-world progression-free survival (rwPFS) and overall survival (OS) were estimated using Kaplan–Meier analyses.Results: In the study population (N=143), median age at eribulin initiation was 62 years; 64% were Caucasian, and 67% had triple-negative MBC (TNBC). Eribulin therapy was used in the second to fifth line of therapy in the metastatic setting; median treatment duration was 7.2 months. The overall response rate for eribulin was 59.4%. Median rwPFS and OS from eribulin initiation were 21.4 months (95% CI, 12.9-not estimable [NE]) and 24.2 months (95% CI, 17.5-NE), respectively. In patients with TNBC, median rwPFS and OS from eribulin initiation were 12.0 months (95% CI, 8.8-NE) and 18.3 months (95% CI, 14.9-NE), respectively.Conclusion: These real-world data provide evidence for the clinical effectiveness outcomes of eribulin treatment among MBC patients previously treated with an IO or ADC.Keywords: real world evidence, metastatic breast cancer, immuno-oncology, antibody drug conjugates, eribulin, patient medical chart reviewhttps://www.dovepress.com/early-real-world-treatment-patterns-and-clinical-outcomes-in-patients--peer-reviewed-fulltext-article-BCTTreal world evidencemetastatic breast cancerimmuno-oncologyantibody drug conjugateseribulinpatient medical chart review |
| spellingShingle | Goyal RK Zhang J Davis KL Sluga-O'Callaghan M Kaufman PA Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy Breast Cancer: Targets and Therapy real world evidence metastatic breast cancer immuno-oncology antibody drug conjugates eribulin patient medical chart review |
| title | Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy |
| title_full | Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy |
| title_fullStr | Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy |
| title_full_unstemmed | Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy |
| title_short | Early Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Breast Cancer Treated with Eribulin After Prior Immuno-Oncology or Antibody–Drug Conjugate Therapy |
| title_sort | early real world treatment patterns and clinical outcomes in patients with metastatic breast cancer treated with eribulin after prior immuno oncology or antibody ndash drug conjugate therapy |
| topic | real world evidence metastatic breast cancer immuno-oncology antibody drug conjugates eribulin patient medical chart review |
| url | https://www.dovepress.com/early-real-world-treatment-patterns-and-clinical-outcomes-in-patients--peer-reviewed-fulltext-article-BCTT |
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