Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8

Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8

Abstract Background G9a and the related enzyme GLP were originally identified as histone lysine methyltransferases and then shown to also methylate several other non-histone proteins. Results Here, we performed a comprehensive screen to identify their substrates in mouse embryonic stem cells (mESCs)...

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Main Authors: Takeshi Tsusaka, Masaki Kikuchi, Tadahiro Shimazu, Takehiro Suzuki, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takashi Umehara, Yoichi Shinkai
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Epigenetics & Chromatin
Subjects:
G9a/Ehmt2
GLP/Ehmt1
ATF7IP
MPP8
Non-histone methylation
Transgene silencing
Online Access:http://link.springer.com/article/10.1186/s13072-018-0231-z

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