Laser desorption rapid evaporative ionization mass spectrometry (LD-REIMS) demonstrates a direct impact of hypochlorous acid stress on PQS-mediated quorum sensing in Pseudomonas aeruginosa

Laser desorption rapid evaporative ionization mass spectrometry (LD-REIMS) demonstrates a direct impact of hypochlorous acid stress on PQS-mediated quorum sensing in Pseudomonas aeruginosa

ABSTRACTTo establish infections in human hosts, Pseudomonas aeruginosa must overcome innate immune-generated oxidative stress, such as the hypochlorous acid (HOCl) produced by neutrophils. We set out to find specific biomarkers of oxidative stress through the development of a protocol for the metabo...

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Bibliographic Details
Main Authors: Rob Bradley, Daniel Simon, Livia Spiga, Yuchen Xiang, Zoltan Takats, Huw Williams
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mSystems
Subjects:
Pseudomonas aeruginosa
laser desorption rapid evaporative ionization mass spectrometry
oxidative stress
quorum sensing
hypochlorous acid
hypothiocyanous acid
Online Access:https://journals.asm.org/doi/10.1128/msystems.01165-23

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