Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways

Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenita...

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Bibliographic Details
Main Authors: Haim Werner, Lena Lapkina-Gendler, Laris Achlaug, Karthik Nagaraj, Lina Somri, Danielle Yaron-Saminsky, Metsada Pasmanik-Chor, Rive Sarfstein, Zvi Laron, Shoshana Yakar
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
insulin-like growth factor 1 (IGF1)
IGF1 receptor (IGF1R)
growth hormone receptor (GH-R)
Laron syndrome
cancer protection
thioredoxin-interacting protein (TXNIP)
Online Access:https://www.mdpi.com/2073-4409/8/6/596

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