Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
<i>Background and Objectives</i>: This systematic review and meta-analysis of randomized controlled trials was performed to compare the therapeutic effects and safety profiles of silodosin and tamsulosin for medical expulsive therapy (MET) of ureteral stones. <i>Materials and Metho...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/12/1794 |
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| author | Hae Do Jung Kang Su Cho Dae Young Jun Jae Yong Jeong Young Joon Moon Doo Yong Chung Dong Hyuk Kang Seok Cho Joo Yong Lee |
| author_facet | Hae Do Jung Kang Su Cho Dae Young Jun Jae Yong Jeong Young Joon Moon Doo Yong Chung Dong Hyuk Kang Seok Cho Joo Yong Lee |
| author_sort | Hae Do Jung |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: This systematic review and meta-analysis of randomized controlled trials was performed to compare the therapeutic effects and safety profiles of silodosin and tamsulosin for medical expulsive therapy (MET) of ureteral stones. <i>Materials and Methods:</i> We searched PubMed, EMBASE, the Cochrane Library, and Web of Science to identify articles published before July 2022 that described randomized controlled trials comparing silodosin and tamsulosin for MET of ureteral stones. Endpoints were stone expulsion rate, stone expulsion time, and total complication rate. <i>Results</i>: In total, 14 studies were included in our analysis. The size of ureteral stones was <1 cm. Compared with tamsulosin, silodosin resulted in a significantly higher stone expulsion rate (<i>p</i> < 0.01, odds ratio (OR) = 2.42, 95% confidence interval (CI) = 1.91 to 3.06, <i>I</i><sup>2</sup> = 0%) and significantly shorter stone expulsion time (<i>p</i> < 0.01, mean difference = −3.04, 95% CI = −4.46 to −1.63, <i>I</i><sup>2</sup> = 89%). The total complication rate did not significantly differ between silodosin and tamsulosin (<i>p</i> = 0.33, OR = 1.15, 95% CI = 0.87 to 1.52, <i>I</i><sup>2</sup> = 7%). <i>Conclusions:</i> Compared with tamsulosin, silodosin resulted in significantly better expulsion of ureteral stones <1 cm. The total complication rate did not significantly differ between silodosin and tamsulosin. Thus, silodosin may be superior to tamsulosin for MET of ureter stones <1 cm. |
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| language | English |
| last_indexed | 2024-03-09T16:07:17Z |
| publishDate | 2022-12-01 |
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| series | Medicina |
| spelling | doaj.art-1cc8d3c2a9cb4865981f42f96c89c1db2023-11-24T16:32:51ZengMDPI AGMedicina1010-660X1648-91442022-12-015812179410.3390/medicina58121794Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled TrialsHae Do Jung0Kang Su Cho1Dae Young Jun2Jae Yong Jeong3Young Joon Moon4Doo Yong Chung5Dong Hyuk Kang6Seok Cho7Joo Yong Lee8Department of Urology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, Republic of KoreaDepartment of Urology, Prostate Cancer Center, Gangnam Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul 06273, Republic of KoreaDepartment of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Urology, Inha University College of Medicine, Incheon 22212, Republic of KoreaDepartment of Urology, Inha University College of Medicine, Incheon 22212, Republic of KoreaDepartment of Urology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, Republic of KoreaDepartment of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea<i>Background and Objectives</i>: This systematic review and meta-analysis of randomized controlled trials was performed to compare the therapeutic effects and safety profiles of silodosin and tamsulosin for medical expulsive therapy (MET) of ureteral stones. <i>Materials and Methods:</i> We searched PubMed, EMBASE, the Cochrane Library, and Web of Science to identify articles published before July 2022 that described randomized controlled trials comparing silodosin and tamsulosin for MET of ureteral stones. Endpoints were stone expulsion rate, stone expulsion time, and total complication rate. <i>Results</i>: In total, 14 studies were included in our analysis. The size of ureteral stones was <1 cm. Compared with tamsulosin, silodosin resulted in a significantly higher stone expulsion rate (<i>p</i> < 0.01, odds ratio (OR) = 2.42, 95% confidence interval (CI) = 1.91 to 3.06, <i>I</i><sup>2</sup> = 0%) and significantly shorter stone expulsion time (<i>p</i> < 0.01, mean difference = −3.04, 95% CI = −4.46 to −1.63, <i>I</i><sup>2</sup> = 89%). The total complication rate did not significantly differ between silodosin and tamsulosin (<i>p</i> = 0.33, OR = 1.15, 95% CI = 0.87 to 1.52, <i>I</i><sup>2</sup> = 7%). <i>Conclusions:</i> Compared with tamsulosin, silodosin resulted in significantly better expulsion of ureteral stones <1 cm. The total complication rate did not significantly differ between silodosin and tamsulosin. Thus, silodosin may be superior to tamsulosin for MET of ureter stones <1 cm.https://www.mdpi.com/1648-9144/58/12/1794ureteral calculiadrenergic alpha-1 receptor antagonistssystematic reviewmeta-analysis |
| spellingShingle | Hae Do Jung Kang Su Cho Dae Young Jun Jae Yong Jeong Young Joon Moon Doo Yong Chung Dong Hyuk Kang Seok Cho Joo Yong Lee Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials Medicina ureteral calculi adrenergic alpha-1 receptor antagonists systematic review meta-analysis |
| title | Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Silodosin versus Tamsulosin for Medical Expulsive Therapy of Ureteral Stones: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | silodosin versus tamsulosin for medical expulsive therapy of ureteral stones an updated systematic review and meta analysis of randomized controlled trials |
| topic | ureteral calculi adrenergic alpha-1 receptor antagonists systematic review meta-analysis |
| url | https://www.mdpi.com/1648-9144/58/12/1794 |
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