How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer. Specifically, we focus on alterations of histone modifications a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/468 |
| _version_ | 1797488492852281344 |
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| author | Anne-Marie Galow Shahaf Peleg |
| author_facet | Anne-Marie Galow Shahaf Peleg |
| author_sort | Anne-Marie Galow |
| collection | DOAJ |
| description | Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer. Specifically, we focus on alterations of histone modifications and DNA methylation and illustrate the link with metabolic pathways. Age-related epigenetic, transcriptional and metabolic deregulations are highly interconnected, which renders dissociating cause and effect complicated. However, growing amounts of evidence support the notion that aging is not only accompanied by epigenetic alterations, but also at least in part induced by those. DNA methylation clocks emerged as a tool to objectively determine biological aging and turned out as a valuable source in search of factors positively and negatively impacting human life span. Moreover, specific epigenetic signatures can be used as biomarkers for age-associated disorders or even as targets for therapeutic approaches, as will be covered in this review. Finally, we summarize recent potential intervention strategies that target epigenetic mechanisms to extend healthy life span and provide an outlook on future developments in the field of longevity research. |
| first_indexed | 2024-03-10T00:02:59Z |
| format | Article |
| id | doaj.art-1cc91ca418004a8dbca3533b40dfa081 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:02:59Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1cc91ca418004a8dbca3533b40dfa0812023-11-23T16:12:24ZengMDPI AGCells2073-44092022-01-0111346810.3390/cells11030468How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life SpanAnne-Marie Galow0Shahaf Peleg1Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, GermanyResearch Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, GermanyEpigenetic alterations pose one major hallmark of organismal aging. Here, we provide an overview on recent findings describing the epigenetic changes that arise during aging and in related maladies such as neurodegeneration and cancer. Specifically, we focus on alterations of histone modifications and DNA methylation and illustrate the link with metabolic pathways. Age-related epigenetic, transcriptional and metabolic deregulations are highly interconnected, which renders dissociating cause and effect complicated. However, growing amounts of evidence support the notion that aging is not only accompanied by epigenetic alterations, but also at least in part induced by those. DNA methylation clocks emerged as a tool to objectively determine biological aging and turned out as a valuable source in search of factors positively and negatively impacting human life span. Moreover, specific epigenetic signatures can be used as biomarkers for age-associated disorders or even as targets for therapeutic approaches, as will be covered in this review. Finally, we summarize recent potential intervention strategies that target epigenetic mechanisms to extend healthy life span and provide an outlook on future developments in the field of longevity research.https://www.mdpi.com/2073-4409/11/3/468histone modificationDNA methylationmetabolismlongevityhealth spanbiomarker |
| spellingShingle | Anne-Marie Galow Shahaf Peleg How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span Cells histone modification DNA methylation metabolism longevity health span biomarker |
| title | How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span |
| title_full | How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span |
| title_fullStr | How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span |
| title_full_unstemmed | How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span |
| title_short | How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span |
| title_sort | how to slow down the ticking clock age associated epigenetic alterations and related interventions to extend life span |
| topic | histone modification DNA methylation metabolism longevity health span biomarker |
| url | https://www.mdpi.com/2073-4409/11/3/468 |
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