Association of handgrip strength with new-onset CKD in Korean adults according to gender
IntroductionHandgrip strength (HGS) is an indicator of many diseases such as pneumonia, cardiovascular disease and cancer. HGS can also predict renal function in chronic kidney disease (CKD) patients, but the value of HGS as a predictor of new-onset CKD is unknown.Methods173,195 subjects were recrui...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1148386/full |
| _version_ | 1797799542342549504 |
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| author | Sung-Bum Lee Sung-Bum Lee Miryung Kim Hui-Jeong Lee Jong-Koo Kim Jong-Koo Kim |
| author_facet | Sung-Bum Lee Sung-Bum Lee Miryung Kim Hui-Jeong Lee Jong-Koo Kim Jong-Koo Kim |
| author_sort | Sung-Bum Lee |
| collection | DOAJ |
| description | IntroductionHandgrip strength (HGS) is an indicator of many diseases such as pneumonia, cardiovascular disease and cancer. HGS can also predict renal function in chronic kidney disease (CKD) patients, but the value of HGS as a predictor of new-onset CKD is unknown.Methods173,195 subjects were recruited from a nationwide cohort and were followed for 4.1 years. After exclusions, 35,757 participants remained in the final study, and CKD developed in 1063 individuals during the follow-up period. Lifestyle, anthropometric and laboratory data were evaluated in relation to the risk of CKD.ResultsThe participants were subdivided into quartiles according to relative handgrip strength (RGS). Multivariate Cox regression demonstrated that RGS was inversely associated with incident CKD. Compared with the lowest quartile, the hazard ratios (HRs) [95% confidence intervals (CIs)] for incident CKD for the highest quartile (Q4) was 0.55 (0.34–0.88) after adjusting for covariates in men and 0.51 (0.31–0.85) in women. The incidence of CKD decreased as RGS increased. These negative associations were more significant in men than in women. The receiver operating characteristic (ROC) curve showed that baseline RGS had predictive power for new-onset CKD. Area under the curve (AUC) (95% CIs) was 0.739 (0.707–0.770) in men and 0.765 (0.729–0.801) in women.ConclusionThis is the novel study demonstrating that RGS is associated with incident CKD in both men and women. The relationship between RGS and incident CKD is more significant in women than in men. RGS can be used in clinical practice to evaluate renal prognosis. Regular measurement of handgrip strength is essential to CKD detection. |
| first_indexed | 2024-03-13T04:20:26Z |
| format | Article |
| id | doaj.art-1cc95a6a305c499e9f2efbc91fd6f319 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T04:20:26Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-1cc95a6a305c499e9f2efbc91fd6f3192023-06-20T10:03:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11483861148386Association of handgrip strength with new-onset CKD in Korean adults according to genderSung-Bum Lee0Sung-Bum Lee1Miryung Kim2Hui-Jeong Lee3Jong-Koo Kim4Jong-Koo Kim5Department of Family Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of KoreaDepartment of Medicine, Graduate School, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaDepartment of Nephrology, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaDepartment of Family Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of KoreaDepartment of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaInstitute of Global Health Care and Development, Wonju, Republic of KoreaIntroductionHandgrip strength (HGS) is an indicator of many diseases such as pneumonia, cardiovascular disease and cancer. HGS can also predict renal function in chronic kidney disease (CKD) patients, but the value of HGS as a predictor of new-onset CKD is unknown.Methods173,195 subjects were recruited from a nationwide cohort and were followed for 4.1 years. After exclusions, 35,757 participants remained in the final study, and CKD developed in 1063 individuals during the follow-up period. Lifestyle, anthropometric and laboratory data were evaluated in relation to the risk of CKD.ResultsThe participants were subdivided into quartiles according to relative handgrip strength (RGS). Multivariate Cox regression demonstrated that RGS was inversely associated with incident CKD. Compared with the lowest quartile, the hazard ratios (HRs) [95% confidence intervals (CIs)] for incident CKD for the highest quartile (Q4) was 0.55 (0.34–0.88) after adjusting for covariates in men and 0.51 (0.31–0.85) in women. The incidence of CKD decreased as RGS increased. These negative associations were more significant in men than in women. The receiver operating characteristic (ROC) curve showed that baseline RGS had predictive power for new-onset CKD. Area under the curve (AUC) (95% CIs) was 0.739 (0.707–0.770) in men and 0.765 (0.729–0.801) in women.ConclusionThis is the novel study demonstrating that RGS is associated with incident CKD in both men and women. The relationship between RGS and incident CKD is more significant in women than in men. RGS can be used in clinical practice to evaluate renal prognosis. Regular measurement of handgrip strength is essential to CKD detection.https://www.frontiersin.org/articles/10.3389/fmed.2023.1148386/fullhandgrip strengthsarcopeniachronic kidney diseaserenal functiongender difference |
| spellingShingle | Sung-Bum Lee Sung-Bum Lee Miryung Kim Hui-Jeong Lee Jong-Koo Kim Jong-Koo Kim Association of handgrip strength with new-onset CKD in Korean adults according to gender Frontiers in Medicine handgrip strength sarcopenia chronic kidney disease renal function gender difference |
| title | Association of handgrip strength with new-onset CKD in Korean adults according to gender |
| title_full | Association of handgrip strength with new-onset CKD in Korean adults according to gender |
| title_fullStr | Association of handgrip strength with new-onset CKD in Korean adults according to gender |
| title_full_unstemmed | Association of handgrip strength with new-onset CKD in Korean adults according to gender |
| title_short | Association of handgrip strength with new-onset CKD in Korean adults according to gender |
| title_sort | association of handgrip strength with new onset ckd in korean adults according to gender |
| topic | handgrip strength sarcopenia chronic kidney disease renal function gender difference |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1148386/full |
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