Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study
Background: Diabetic ketoacidosis (DKA) can cause several complications. The myocardial damage in children with DKA was not evaluated clearly. This study aimed to investigate the troponin level as a biochemical marker of myocardial damage in children with DKA during the disease and after recovery....
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Tehran University of Medical Sciences
2022-10-01
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| Series: | Journal of Tehran University Heart Center |
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| Online Access: | https://jthc.tums.ac.ir/index.php/jthc/article/view/1673 |
| _version_ | 1797943693865385984 |
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| author | Nima Mehdizadegan Homa Ilkanipoor Pegah Rezaee Negar Yazdani Hamid Amoozgar Fatemeh Sadat Mirrashidi Hossein Moravej |
| author_facet | Nima Mehdizadegan Homa Ilkanipoor Pegah Rezaee Negar Yazdani Hamid Amoozgar Fatemeh Sadat Mirrashidi Hossein Moravej |
| author_sort | Nima Mehdizadegan |
| collection | DOAJ |
| description |
Background: Diabetic ketoacidosis (DKA) can cause several complications. The myocardial damage in children with DKA was not evaluated clearly. This study aimed to investigate the troponin level as a biochemical marker of myocardial damage in children with DKA during the disease and after recovery.
Methods: This cross-sectional study was conducted in the pediatric endocrinology department of Namazi Hospital, Shiraz, Iran, from May to December 2019. Fifty diabetic children aged 1 to 18 years old with DKA by census sampling method. All patients were examed, and electrocardiography (ECG) was carried out. Troponin level was measured at admission and 48 hours after recovery. Finally, data were analysed using SPSS software 20.
Results: At the time of admission, the mean troponin level was 11.56±5.35 ng/mL and it became 2.15±1.21 ng/mL after recovery. Although the initial troponin level during DKA in three patients was higher than the expected normal reference range, their echocardiography and ECG were normal. Moreover, there was no statistical relationship between troponin level with age, diabetes duration, and DKA severity.
Conclusion: The troponin level was remarkably different during DKA and after recovery. However, in merely 6% of DKA patients, the troponin level was higher than the expected value. We recommended that these patients be followed for future cardiovascular complications.
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| first_indexed | 2024-04-10T20:28:15Z |
| format | Article |
| id | doaj.art-1cca4d6199904c219bd38ddb69ff43e1 |
| institution | Directory Open Access Journal |
| issn | 1735-8620 2008-2371 |
| language | English |
| last_indexed | 2024-04-10T20:28:15Z |
| publishDate | 2022-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-1cca4d6199904c219bd38ddb69ff43e12023-01-25T07:58:04ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712022-10-0117410.18502/jthc.v17i4.11616Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional studyNima Mehdizadegan0Homa Ilkanipoor1Pegah Rezaee2Negar Yazdani3Hamid Amoozgar4Fatemeh Sadat Mirrashidi5Hossein Moravej6Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics Endocrinology and Metabolism, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran.Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, IranCardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, Jiroft University of Medical Sciences, Jiroft, IranNeonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Background: Diabetic ketoacidosis (DKA) can cause several complications. The myocardial damage in children with DKA was not evaluated clearly. This study aimed to investigate the troponin level as a biochemical marker of myocardial damage in children with DKA during the disease and after recovery. Methods: This cross-sectional study was conducted in the pediatric endocrinology department of Namazi Hospital, Shiraz, Iran, from May to December 2019. Fifty diabetic children aged 1 to 18 years old with DKA by census sampling method. All patients were examed, and electrocardiography (ECG) was carried out. Troponin level was measured at admission and 48 hours after recovery. Finally, data were analysed using SPSS software 20. Results: At the time of admission, the mean troponin level was 11.56±5.35 ng/mL and it became 2.15±1.21 ng/mL after recovery. Although the initial troponin level during DKA in three patients was higher than the expected normal reference range, their echocardiography and ECG were normal. Moreover, there was no statistical relationship between troponin level with age, diabetes duration, and DKA severity. Conclusion: The troponin level was remarkably different during DKA and after recovery. However, in merely 6% of DKA patients, the troponin level was higher than the expected value. We recommended that these patients be followed for future cardiovascular complications. https://jthc.tums.ac.ir/index.php/jthc/article/view/1673TroponinDiabetic KetoacidosisPediatricsCardiovascularComplications |
| spellingShingle | Nima Mehdizadegan Homa Ilkanipoor Pegah Rezaee Negar Yazdani Hamid Amoozgar Fatemeh Sadat Mirrashidi Hossein Moravej Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study Journal of Tehran University Heart Center Troponin Diabetic Ketoacidosis Pediatrics Cardiovascular Complications |
| title | Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study |
| title_full | Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study |
| title_fullStr | Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study |
| title_full_unstemmed | Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study |
| title_short | Serum troponin I level in children with diabetic ketoacidosis: a cross-sectional study |
| title_sort | serum troponin i level in children with diabetic ketoacidosis a cross sectional study |
| topic | Troponin Diabetic Ketoacidosis Pediatrics Cardiovascular Complications |
| url | https://jthc.tums.ac.ir/index.php/jthc/article/view/1673 |
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