Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia
BackgroundPostoperative nausea and vomiting (PONV) is the major complication related to general anesthesia, occurring in 60–80% of patients after thyroidectomy. The objective of this study was to compare the effects of an intraoperative dexmedetomidine infusion with remifentanil, as anesthetic adjuv...
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Korean Society of Anesthesiologists
2017-06-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-70-299.pdf |
| _version_ | 1828932458472538112 |
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| author | Eun Kyung Choi Yijun Seo Dong Gun Lim Sungsik Park |
| author_facet | Eun Kyung Choi Yijun Seo Dong Gun Lim Sungsik Park |
| author_sort | Eun Kyung Choi |
| collection | DOAJ |
| description | BackgroundPostoperative nausea and vomiting (PONV) is the major complication related to general anesthesia, occurring in 60–80% of patients after thyroidectomy. The objective of this study was to compare the effects of an intraoperative dexmedetomidine infusion with remifentanil, as anesthetic adjuvants of balanced anesthesia, on PONV in patients undergoing thyroidectomy.MethodsEighty patients scheduled for thyroidectomy were randomized into the following two groups: 1) The dexmedetomidine group (Group D), who received an initial loading dose of dexmedetomidine (1 µg/kg over 10 min) during the induction of anesthesia, followed by a continuous infusion at a rate of 0.3–0.5 µg/kg/h; 2) the remifentanil group (group R), who received remifentanil at an initial target effect site concentration of 4 ng/ml during the induction of anesthesia, followed by a target effect site concentration of 2–3 ng/ml. PONV was assessed during the first 24 hours in 2 time periods (0–2 h and 2–24 h). The pain intensity, sedation score, extubation time, and hemodynamics were also assessed.ResultsDuring the 2 time periods, the incidence and severity of PONV in group D were significantly lower than in group R. In addition, the need for rescue antiemetics was significantly lower in group D than in group R. The effect of dexmedetomidine on postoperative pain relief (2–24 h) was superior to that of remifentanil. The hemodynamics were similar in both groups, whereas eye opening and extubation time were delayed in group D.ConclusionsAdjuvant use of intraoperative dexmedetomidine infusion may be effective for the prevention of PONV. |
| first_indexed | 2024-12-14T01:02:28Z |
| format | Article |
| id | doaj.art-1ccac5cf72ec45e3ad44452768d79c91 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-14T01:02:28Z |
| publishDate | 2017-06-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-1ccac5cf72ec45e3ad44452768d79c912022-12-21T23:23:10ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632017-06-0170329930410.4097/kjae.2017.70.3.2998299Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesiaEun Kyung Choi0Yijun Seo1Dong Gun Lim2Sungsik Park3Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine, Daegu, Korea.Department of Anesthesiology and Pain Medicine, Kyungpook National University School of Medicine, Daegu, Korea.Department of Anesthesiology and Pain Medicine, Kyungpook National University School of Medicine, Daegu, Korea.Department of Anesthesiology and Pain Medicine, Kyungpook National University School of Medicine, Daegu, Korea.BackgroundPostoperative nausea and vomiting (PONV) is the major complication related to general anesthesia, occurring in 60–80% of patients after thyroidectomy. The objective of this study was to compare the effects of an intraoperative dexmedetomidine infusion with remifentanil, as anesthetic adjuvants of balanced anesthesia, on PONV in patients undergoing thyroidectomy.MethodsEighty patients scheduled for thyroidectomy were randomized into the following two groups: 1) The dexmedetomidine group (Group D), who received an initial loading dose of dexmedetomidine (1 µg/kg over 10 min) during the induction of anesthesia, followed by a continuous infusion at a rate of 0.3–0.5 µg/kg/h; 2) the remifentanil group (group R), who received remifentanil at an initial target effect site concentration of 4 ng/ml during the induction of anesthesia, followed by a target effect site concentration of 2–3 ng/ml. PONV was assessed during the first 24 hours in 2 time periods (0–2 h and 2–24 h). The pain intensity, sedation score, extubation time, and hemodynamics were also assessed.ResultsDuring the 2 time periods, the incidence and severity of PONV in group D were significantly lower than in group R. In addition, the need for rescue antiemetics was significantly lower in group D than in group R. The effect of dexmedetomidine on postoperative pain relief (2–24 h) was superior to that of remifentanil. The hemodynamics were similar in both groups, whereas eye opening and extubation time were delayed in group D.ConclusionsAdjuvant use of intraoperative dexmedetomidine infusion may be effective for the prevention of PONV.http://ekja.org/upload/pdf/kjae-70-299.pdfdexmedetomidinepostoperative nausea and vomitingremifentanil |
| spellingShingle | Eun Kyung Choi Yijun Seo Dong Gun Lim Sungsik Park Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia Korean Journal of Anesthesiology dexmedetomidine postoperative nausea and vomiting remifentanil |
| title | Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia |
| title_full | Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia |
| title_fullStr | Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia |
| title_full_unstemmed | Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia |
| title_short | Postoperative nausea and vomiting after thyroidectomy: a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia |
| title_sort | postoperative nausea and vomiting after thyroidectomy a comparison between dexmedetomidine and remifentanil as part of balanced anesthesia |
| topic | dexmedetomidine postoperative nausea and vomiting remifentanil |
| url | http://ekja.org/upload/pdf/kjae-70-299.pdf |
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