Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation
Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as a key cargo in proliferating CD4+ T cells.
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32718-x |
| _version_ | 1811274864348102656 |
|---|---|
| author | Dingxi Zhou Mariana Borsa Daniel J. Puleston Susanne Zellner Jesusa Capera Sharon Sanderson Martina Schifferer Svenja S. Hester Xin Ge Roman Fischer Luke Jostins Christian Behrends Ghada Alsaleh Anna Katharina Simon |
| author_facet | Dingxi Zhou Mariana Borsa Daniel J. Puleston Susanne Zellner Jesusa Capera Sharon Sanderson Martina Schifferer Svenja S. Hester Xin Ge Roman Fischer Luke Jostins Christian Behrends Ghada Alsaleh Anna Katharina Simon |
| author_sort | Dingxi Zhou |
| collection | DOAJ |
| description | Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as a key cargo in proliferating CD4+ T cells. |
| first_indexed | 2024-04-12T23:26:48Z |
| format | Article |
| id | doaj.art-1ccb857c105547c5b33bd8c47532fb9e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T23:26:48Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1ccb857c105547c5b33bd8c47532fb9e2022-12-22T03:12:23ZengNature PortfolioNature Communications2041-17232022-09-0113111510.1038/s41467-022-32718-xMapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferationDingxi Zhou0Mariana Borsa1Daniel J. Puleston2Susanne Zellner3Jesusa Capera4Sharon Sanderson5Martina Schifferer6Svenja S. Hester7Xin Ge8Roman Fischer9Luke Jostins10Christian Behrends11Ghada Alsaleh12Anna Katharina Simon13The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordMunich Cluster for Systems Neurology (SyNergy), Medical Faculty, Ludwig-Maximilians-University MünchenThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordGerman Center for Neurodegenerative Diseases (DZNE)Nuffield Department of Medicine, Target Discovery Institute, University of OxfordThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordNuffield Department of Medicine, Target Discovery Institute, University of OxfordThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordMunich Cluster for Systems Neurology (SyNergy), Medical Faculty, Ludwig-Maximilians-University MünchenThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of OxfordAutophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as a key cargo in proliferating CD4+ T cells.https://doi.org/10.1038/s41467-022-32718-x |
| spellingShingle | Dingxi Zhou Mariana Borsa Daniel J. Puleston Susanne Zellner Jesusa Capera Sharon Sanderson Martina Schifferer Svenja S. Hester Xin Ge Roman Fischer Luke Jostins Christian Behrends Ghada Alsaleh Anna Katharina Simon Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation Nature Communications |
| title | Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation |
| title_full | Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation |
| title_fullStr | Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation |
| title_full_unstemmed | Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation |
| title_short | Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation |
| title_sort | mapping autophagosome contents identifies interleukin 7 receptor α as a key cargo modulating cd4 t cell proliferation |
| url | https://doi.org/10.1038/s41467-022-32718-x |
| work_keys_str_mv | AT dingxizhou mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT marianaborsa mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT danieljpuleston mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT susannezellner mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT jesusacapera mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT sharonsanderson mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT martinaschifferer mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT svenjashester mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT xinge mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT romanfischer mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT lukejostins mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT christianbehrends mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT ghadaalsaleh mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation AT annakatharinasimon mappingautophagosomecontentsidentifiesinterleukin7receptoraasakeycargomodulatingcd4tcellproliferation |