Biophysical Compatibility of a Heterotrimeric Tyrosinase-TYRP1-TYRP2 Metalloenzyme Complex
Tyrosinase (TYR) is a copper-containing monooxygenase central to the function of melanocytes. Alterations in its expression or activity contribute to variations in skin, hair and eye color, and underlie a variety of pathogenic pigmentary phenotypes, including several forms of oculocutaneous albinism...
Main Authors: | Olga Lavinda, Prashiela Manga, Seth J. Orlow, Timothy Cardozo |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-04-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.602206/full |
Similar Items
-
Tyrosinase Nanoparticles: Understanding the Melanogenesis Pathway by Isolating the Products of Tyrosinase Enzymatic Reaction
by: Paul K. Varghese, et al.
Published: (2021-01-01) -
In Vitro Reconstitution of the Melanin Pathway’s Catalytic Activities Using Tyrosinase Nanoparticles
by: Isabella Osuna, et al.
Published: (2022-12-01) -
Protein Biochemistry and Molecular Modeling of the Intra-Melanosomal Domain of Human Recombinant Tyrp2 Protein and OCA8-Related Mutant Variants
by: Monika B. Dolinska, et al.
Published: (2022-01-01) -
Identification of c.483C>T polymorphism in the caprine tyrosinase-related protein 1 (TYRP1) gene
by: Bouabid Badaoui, et al.
Published: (2012-03-01) -
Identification of c.483C>T polymorphism in the caprine tyrosinase-related protein 1 (TYRP1) gene
by: Marcel Amills, et al.
Published: (2012-01-01)