Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine)
Background: The differences in the resting state spectral power and functional connectivity of the default mode network between people with migraine without aura (MwoA) and its subgroups differentiated by frequency (episodic migraine (EM) and chronic migraine (CM)) and healthy controls (HC) were inv...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-01-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301019 |
| _version_ | 1797338799621013504 |
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| author | Xiaofang Zhang Fengyuan Xu Di Wu Yingfan Wang Qiqi Chen Fangling Sun Yihan Li Xiaoshan Wang |
| author_facet | Xiaofang Zhang Fengyuan Xu Di Wu Yingfan Wang Qiqi Chen Fangling Sun Yihan Li Xiaoshan Wang |
| author_sort | Xiaofang Zhang |
| collection | DOAJ |
| description | Background: The differences in the resting state spectral power and functional connectivity of the default mode network between people with migraine without aura (MwoA) and its subgroups differentiated by frequency (episodic migraine (EM) and chronic migraine (CM)) and healthy controls (HC) were investigated using magnetoencephalography. Methods: In the resting state, the topological spatial structure of the brain in 33 MwoA patients and 22 HC was first studied using magnetoencephalography, followed by probing the neuroelectrical activity of 17 CM and 16 EM patients, to identify damage to their default mode network (DMN). The techniques used to investigate both spectral power and functional connectivity were minimum-paradigm estimation combined with Welch’s technique and corrected amplitude envelope correlation. Results: The differences between MwoA and its subgroups (CM and EM) and HC based on spectral power were mainly in the delta, theta, and alpha bands, while the differences in functional connectivity were primarily in the delta, alpha, and beta bands. In the delta and theta bands, the spectral power of MwoA and its subgroups (CM and EM) was higher than in the HC group. The spectral power of MwoA and its subgroups (CM and EM) was lower in the alpha band. In terms of functional connectivity, the corrected amplitude envelope correlation of MwoA and its subgroups (CM and EM) was lower than the HC group in the bands with spectral differences. People with EM and CM differed in the spectral power in the left medial prefrontal cortex and the right lateral temporal cortex in the alpha band, where correlation analysis and logistic regression analysis showed that the intensity of the spectral power of the left medial prefrontal cortex was negatively correlated with headache frequency. Conclusions: The spectral power of the left medial prefrontal cortex in the alpha band may serve as a biomarker that is associated with the number of monthly headache attacks and may be a potential neuromodulatory target for controlling migraine chronicity. |
| first_indexed | 2024-03-08T09:36:31Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-08T09:36:31Z |
| publishDate | 2024-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-1ccdc6fff3b7403ca300fdda6572d6af2024-01-30T07:44:43ZengIMR PressJournal of Integrative Neuroscience0219-63522024-01-012311910.31083/j.jin2301019S0219-6352(23)00607-1Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine)Xiaofang Zhang0Fengyuan Xu1Di Wu2Yingfan Wang3Qiqi Chen4Fangling Sun5Yihan Li6Xiaoshan Wang7Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaMEG Center, The Affiliated Brain Hospital of Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, 210003 Nanjing, Jiangsu, ChinaBackground: The differences in the resting state spectral power and functional connectivity of the default mode network between people with migraine without aura (MwoA) and its subgroups differentiated by frequency (episodic migraine (EM) and chronic migraine (CM)) and healthy controls (HC) were investigated using magnetoencephalography. Methods: In the resting state, the topological spatial structure of the brain in 33 MwoA patients and 22 HC was first studied using magnetoencephalography, followed by probing the neuroelectrical activity of 17 CM and 16 EM patients, to identify damage to their default mode network (DMN). The techniques used to investigate both spectral power and functional connectivity were minimum-paradigm estimation combined with Welch’s technique and corrected amplitude envelope correlation. Results: The differences between MwoA and its subgroups (CM and EM) and HC based on spectral power were mainly in the delta, theta, and alpha bands, while the differences in functional connectivity were primarily in the delta, alpha, and beta bands. In the delta and theta bands, the spectral power of MwoA and its subgroups (CM and EM) was higher than in the HC group. The spectral power of MwoA and its subgroups (CM and EM) was lower in the alpha band. In terms of functional connectivity, the corrected amplitude envelope correlation of MwoA and its subgroups (CM and EM) was lower than the HC group in the bands with spectral differences. People with EM and CM differed in the spectral power in the left medial prefrontal cortex and the right lateral temporal cortex in the alpha band, where correlation analysis and logistic regression analysis showed that the intensity of the spectral power of the left medial prefrontal cortex was negatively correlated with headache frequency. Conclusions: The spectral power of the left medial prefrontal cortex in the alpha band may serve as a biomarker that is associated with the number of monthly headache attacks and may be a potential neuromodulatory target for controlling migraine chronicity.https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301019mwoacmemdmnmagnetoencephalography |
| spellingShingle | Xiaofang Zhang Fengyuan Xu Di Wu Yingfan Wang Qiqi Chen Fangling Sun Yihan Li Xiaoshan Wang Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine) Journal of Integrative Neuroscience mwoa cm em dmn magnetoencephalography |
| title | Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine) |
| title_full | Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine) |
| title_fullStr | Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine) |
| title_full_unstemmed | Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine) |
| title_short | Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine) |
| title_sort | altered neuromagnetic activity in the default mode network in migraine and its subgroups episodic migraine and chronic migraine |
| topic | mwoa cm em dmn magnetoencephalography |
| url | https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301019 |
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