Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?
Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy Abstract: Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-09-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/resolvins-and-aliamides-lipid-autacoids-in-ophthalmology-ndash-what-pr-peer-reviewed-article-DDDT |
| _version_ | 1818238899667861504 |
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| author | Hesselink JMK Chiosi F Costagliola C |
| author_facet | Hesselink JMK Chiosi F Costagliola C |
| author_sort | Hesselink JMK |
| collection | DOAJ |
| description | Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy Abstract: Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives – RX-10045. Keywords: resolvins, autacoids, aliamides, dry eye, palmitoylethanolamide, inflammation, ophthalmology, protection |
| first_indexed | 2024-12-12T12:48:59Z |
| format | Article |
| id | doaj.art-1ccdfabe82f146278aef84ebc241e677 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-12T12:48:59Z |
| publishDate | 2016-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-1ccdfabe82f146278aef84ebc241e6772022-12-22T00:24:03ZengDove Medical PressDrug Design, Development and Therapy1177-88812016-09-01Volume 103133314129149Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?Hesselink JMKChiosi FCostagliola CJan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy Abstract: Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives – RX-10045. Keywords: resolvins, autacoids, aliamides, dry eye, palmitoylethanolamide, inflammation, ophthalmology, protectionhttps://www.dovepress.com/resolvins-and-aliamides-lipid-autacoids-in-ophthalmology-ndash-what-pr-peer-reviewed-article-DDDTresolvinsautacoidsaliamidesdry eyepalmitoylethanolamide |
| spellingShingle | Hesselink JMK Chiosi F Costagliola C Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? Drug Design, Development and Therapy resolvins autacoids aliamides dry eye palmitoylethanolamide |
| title | Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? |
| title_full | Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? |
| title_fullStr | Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? |
| title_full_unstemmed | Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? |
| title_short | Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? |
| title_sort | resolvins and aliamides lipid autacoids in ophthalmology ndash what promise do they hold |
| topic | resolvins autacoids aliamides dry eye palmitoylethanolamide |
| url | https://www.dovepress.com/resolvins-and-aliamides-lipid-autacoids-in-ophthalmology-ndash-what-pr-peer-reviewed-article-DDDT |
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