Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisyste...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/10/5/889 |
| _version_ | 1827741671763214336 |
|---|---|
| author | Camilla Astley Gabriela Nunes Leal Saulo Gil Priscila Suguita Thais Fink Vera Bain Maria Fernanda Badue Pereira Heloisa Helena Marques Sofia Sieczkowska Danilo Prado Marcos Santos Lima Camila G. Carneiro Carlos Alberto Buchpiguel Clovis Artur Silva Bruno Gualano |
| author_facet | Camilla Astley Gabriela Nunes Leal Saulo Gil Priscila Suguita Thais Fink Vera Bain Maria Fernanda Badue Pereira Heloisa Helena Marques Sofia Sieczkowska Danilo Prado Marcos Santos Lima Camila G. Carneiro Carlos Alberto Buchpiguel Clovis Artur Silva Bruno Gualano |
| author_sort | Camilla Astley |
| collection | DOAJ |
| description | Objective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7–16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings. |
| first_indexed | 2024-03-11T03:50:25Z |
| format | Article |
| id | doaj.art-1ccf3727b4e949039794aacb847c4e59 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T03:50:25Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-1ccf3727b4e949039794aacb847c4e592023-11-18T00:56:25ZengMDPI AGChildren2227-90672023-05-0110588910.3390/children10050889Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series StudyCamilla Astley0Gabriela Nunes Leal1Saulo Gil2Priscila Suguita3Thais Fink4Vera Bain5Maria Fernanda Badue Pereira6Heloisa Helena Marques7Sofia Sieczkowska8Danilo Prado9Marcos Santos Lima10Camila G. Carneiro11Carlos Alberto Buchpiguel12Clovis Artur Silva13Bruno Gualano14Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 01246-903, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilApplied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 01246-903, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilApplied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 01246-903, BrazilApplied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 01246-903, BrazilDepartment of Radiology and Oncology, Nuclear Medicine Division, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-911, BrazilDepartment of Radiology and Oncology, Nuclear Medicine Division, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-911, BrazilDepartment of Radiology and Oncology, Nuclear Medicine Division, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-911, BrazilChildren and Adolescent Institute, Clinical Hospital, School of Medicine, University of Sao Paulo, Sao Paulo 05403-000, BrazilApplied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 01246-903, BrazilObjective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7–16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings.https://www.mdpi.com/2227-9067/10/5/889COVID-19pediatric multisystem inflammatory diseasecardiovascular imagingmicrovasculatureexercise training |
| spellingShingle | Camilla Astley Gabriela Nunes Leal Saulo Gil Priscila Suguita Thais Fink Vera Bain Maria Fernanda Badue Pereira Heloisa Helena Marques Sofia Sieczkowska Danilo Prado Marcos Santos Lima Camila G. Carneiro Carlos Alberto Buchpiguel Clovis Artur Silva Bruno Gualano Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study Children COVID-19 pediatric multisystem inflammatory disease cardiovascular imaging microvasculature exercise training |
| title | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
| title_full | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
| title_fullStr | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
| title_full_unstemmed | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
| title_short | Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study |
| title_sort | home based exercise training in the recovery of multisystem inflammatory syndrome in children a case series study |
| topic | COVID-19 pediatric multisystem inflammatory disease cardiovascular imaging microvasculature exercise training |
| url | https://www.mdpi.com/2227-9067/10/5/889 |
| work_keys_str_mv | AT camillaastley homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT gabrielanunesleal homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT saulogil homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT priscilasuguita homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT thaisfink homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT verabain homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT mariafernandabaduepereira homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT heloisahelenamarques homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT sofiasieczkowska homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT daniloprado homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT marcossantoslima homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT camilagcarneiro homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT carlosalbertobuchpiguel homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT clovisartursilva homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy AT brunogualano homebasedexercisetrainingintherecoveryofmultisysteminflammatorysyndromeinchildrenacaseseriesstudy |