Ent-Abietanoids Isolated from Isodon serra
Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified a...
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| Format: | Article |
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/2/309 |
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| author | Jun Wan Hua-Yi Jiang Jian-Wei Tang Xing-Ren Li Xue Du Yan Li Han-Dong Sun Jian-Xin Pu |
| author_facet | Jun Wan Hua-Yi Jiang Jian-Wei Tang Xing-Ren Li Xue Du Yan Li Han-Dong Sun Jian-Xin Pu |
| author_sort | Jun Wan |
| collection | DOAJ |
| description | Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 μM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). |
| first_indexed | 2024-12-11T20:23:57Z |
| format | Article |
| id | doaj.art-1cd00498ddcf484a912356182fed1931 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T20:23:57Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1cd00498ddcf484a912356182fed19312022-12-22T00:51:59ZengMDPI AGMolecules1420-30492017-02-0122230910.3390/molecules22020309molecules22020309Ent-Abietanoids Isolated from Isodon serraJun Wan0Hua-Yi Jiang1Jian-Wei Tang2Xing-Ren Li3Xue Du4Yan Li5Han-Dong Sun6Jian-Xin Pu7State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaFour new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 μM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).http://www.mdpi.com/1420-3049/22/2/309Isodon serraent-abietane diterpenoidsanti-inflammationcytotoxicity |
| spellingShingle | Jun Wan Hua-Yi Jiang Jian-Wei Tang Xing-Ren Li Xue Du Yan Li Han-Dong Sun Jian-Xin Pu Ent-Abietanoids Isolated from Isodon serra Molecules Isodon serra ent-abietane diterpenoids anti-inflammation cytotoxicity |
| title | Ent-Abietanoids Isolated from Isodon serra |
| title_full | Ent-Abietanoids Isolated from Isodon serra |
| title_fullStr | Ent-Abietanoids Isolated from Isodon serra |
| title_full_unstemmed | Ent-Abietanoids Isolated from Isodon serra |
| title_short | Ent-Abietanoids Isolated from Isodon serra |
| title_sort | ent abietanoids isolated from isodon serra |
| topic | Isodon serra ent-abietane diterpenoids anti-inflammation cytotoxicity |
| url | http://www.mdpi.com/1420-3049/22/2/309 |
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